Synonym
Colterol mesylate; Win5563-3; Win -5563-3; Win 5563-3
IUPAC/Chemical Name
1,2-Benzenediol, 4-(2-((1,1-dimethylethyl)amino)-1-hydroxyethyl)- methanesulfonate
InChi Key
KEMVSPGUCYKOQX-UHFFFAOYSA-N
InChi Code
InChI=1S/C13H21NO5S/c1-13(2,3)14-8-11(16)9-5-6-12(10(15)7-9)19-20(4,17)18/h5-7,11,14-16H,8H2,1-4H3
SMILES Code
OC1=CC(C(O)CNC(C)(C)C)=CC=C1OS(C)(=O)=O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
|
Solvent |
mg/mL |
mM |
comments |
| Solubility |
| Soluble in DMSO |
0.0 |
100.00 |
|
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.
Preparing Stock Solutions
The following data is based on the
product
molecular weight
303.37
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Walker SB, Kradjan WA, Bierman CW. Bitolterol mesylate: a beta-adrenergic agent. Chemistry, pharmacokinetics, pharmacodynamics, adverse effects and clinical efficacy in asthma. Pharmacotherapy. 1985 May-Jun;5(3):127-37. doi: 10.1002/j.1875-9114.1985.tb03410.x. PMID: 3895171.
2: Friedel HA, Brogden RN. Bitolterol. A preliminary review of its pharmacological properties and therapeutic efficacy in reversible obstructive airways disease. Drugs. 1988 Jan;35(1):22-41. doi: 10.2165/00003495-198835010-00002. PMID: 3278878.
3: Kusayama T, Oka J, Yabana H, Adachi-Akahane S, Nagao T. Binding of a catechol derivative of denopamine (T-0509) and N-tert-butylnoradrenaline (Colterol) to beta 1- and beta 2-adrenoceptors. Biol Pharm Bull. 1994 Aug;17(8):1023-7. doi: 10.1248/bpb.17.1023. PMID: 7820101.
4: Kelly HW. New beta 2-adrenergic agonist aerosols. Clin Pharm. 1985 Jul- Aug;4(4):393-403. PMID: 2864159.
5: Aimoto T, Ito O, Kimura R, Murata T, Ito K. The influences of the route of administration on the metabolism and excretion of bitolterol, a new bronchodilator, in the rat. Xenobiotica. 1979 Mar;9(3):173-80. doi: 10.3109/00498257909038718. PMID: 473792.
6: Waldeck B, Jeppsson AB, Widmark E. Partial agonism and functional selectivity: a study on beta-adrenoceptor mediated effects in tracheal, cardiac and skeletal muscle. Acta Pharmacol Toxicol (Copenh). 1986 Mar;58(3):209-18. doi: 10.1111/j.1600-0773.1986.tb00096.x. PMID: 2872766.
7: Wilson TD, Fogarty DF. The effect of column age on system suitability parameters for an HPLC assay of bitolterol mesylate aerosols. J Chromatogr Sci. 1988 Feb;26(2):60-6. doi: 10.1093/chromsci/26.2.60. PMID: 3350902.
8: Burroughs AF, Eluhu S, Whalen D, Goodwin JS, Sakwe AM, Arinze IJ. PML-Nuclear Bodies Regulate the Stability of the Fusion Protein Dendra2-Nrf2 in the Nucleus. Cell Physiol Biochem. 2018;47(2):800-816. doi: 10.1159/000490033. Epub 2018 May 22. PMID: 29807365; PMCID: PMC6503657.
9: Park GB, Koss RF, Utter J, Edelson J. Determination of colterol in human plasma and urine by reversed-phase chromatography with amperometric detection. J Chromatogr. 1983 Apr 8;273(2):481-6. doi: 10.1016/s0378-4347(00)80975-5. PMID: 6345565.
10: Prados P, Higashidate S, Imai K, Sato Y, Nagao T. Sensitive determination of (-)-isoproterenol and (-)-(R)-1-(3,4- dihydroxyphenyl)-2-[(3,4-dimethoxyphenethyl)amino] ethanol (T-0509), a cardiotonic agent, in rat plasma utilizing a fully automated catecholamine analyser. Biomed Chromatogr. 1994 Jan-Feb;8(1):49-51. doi: 10.1002/bmc.1130080113. PMID: 8130635.
