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MedKoo Cat#: 413123 | Name: Cinnarizine clofibrate

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Cinnarizine clofibrate is a calcium channel protein inhibitor as well as an antihistamine channel blocker. The compound is a drug derivative of piperazine. Cinnarizine is used for the control of vomiting due to motion sickness. It acts by interfering with the signal transmission between vestibular apparatus of the inner ear and the vomiting centre of the hypothalamus

Chemical Structure

Cinnarizine clofibrate
Cinnarizine clofibrate
CAS#60763-49-7 (cinnarizine)

Theoretical Analysis

MedKoo Cat#: 413123

Name: Cinnarizine clofibrate

CAS#: 60763-49-7 (cinnarizine)

Chemical Formula: C36H39ClN2O3

Exact Mass: 582.2649

Molecular Weight: 583.17

Elemental Analysis: C, 74.15; H, 6.74; Cl, 6.08; N, 4.80; O, 8.23

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
39087-48-4 (calcium) 60763-49-7 (cinnarizine) 637-07-0 (free) 84489-15-6 (mercapturate) 77111-08-1 (lysine) 14613-30-0 (magnesium) 7314-47-8 (sodium)
Synonym
Cinnarizine clofibrate; LM16; LM-16; LM 16; Cinnarizini clofibras; Clofibrato de cinarizina
IUPAC/Chemical Name
2-(p-Chlorophenoxy)-2-methylpropionic acid compound with (E)-1-cinnamyl-4-(diphenylmethyl)piperazine (1:1)
InChi Key
GNQQJMWZCJAUJT-RSGUCCNWSA-N
InChi Code
InChI=1S/C26H28N2.C10H11ClO3/c1-4-11-23(12-5-1)13-10-18-27-19-21-28(22-20-27)26(24-14-6-2-7-15-24)25-16-8-3-9-17-25;1-10(2,9(12)13)14-8-5-3-7(11)4-6-8/h1-17,26H,18-22H2;3-6H,1-2H3,(H,12,13)/b13-10+;
SMILES Code
CC(C)(OC1=CC=C(Cl)C=C1)C(O)=O.N2(C/C=C/C3=CC=CC=C3)CCN(C(C4=CC=CC=C4)C5=CC=CC=C5)CC2
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 583.17 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Metz G, Specker M. Hypolipemic activity of clofibrate-related compounds. 2nd Communication. Arzneimittelforschung. 1977 Jul;27(7):1421-4. PMID: 578466. 2: Sobczyk W. Porównawcza ocena skuteczności terapeutycznej leków z róznymi mechanizmami działania w miazdzycy mózgu [Comparative evaluation of the therapeutic effectiveness of drugs of different mechanisms of action in cerebral atherosclerosis]. Neurol Neurochir Pol. 1982 Jul-Aug;16(4):245-60. Polish. PMID: 7145012.