MedKoo Cat#: 413115 | Name: Magnesium clofibrate

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Magnesium clofibrate is a magnesium salt formulation of clofibrate, an aryloxyisobutyric acid derivate with antihyperlipidemic activity.

Chemical Structure

Magnesium clofibrate
Magnesium clofibrate
CAS#14613-30-0 (magnesium)

Theoretical Analysis

MedKoo Cat#: 413115

Name: Magnesium clofibrate

CAS#: 14613-30-0 (magnesium)

Chemical Formula: C20H20Cl2MgO6

Exact Mass: 450.0487

Molecular Weight: 451.57

Elemental Analysis: C, 53.20; H, 4.46; Cl, 15.70; Mg, 5.38; O, 21.26

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Synonym
Magnesium clofibrate; Clomag; UR112; UR-112; UR 112
IUPAC/Chemical Name
magnesium 2-(4-chlorophenoxy)-2-methylpropanoate
InChi Key
SYMULEBHDFQHNX-UHFFFAOYSA-L
InChi Code
InChI=1S/2C10H11ClO3.Mg/c2*1-10(2,9(12)13)14-8-5-3-7(11)4-6-8;/h2*3-6H,1-2H3,(H,12,13);/q;;+2/p-2
SMILES Code
CC(C)(OC1=CC=C(Cl)C=C1)C([O-])=O.CC(C)(OC2=CC=C(Cl)C=C2)C([O-])=O.[Mg+2]
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 451.57 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Paltauf F, Pristautz H, el Eisch IA. Pharmakokinetik einer Kombination von Magnesium-Chlorphenoxy-Isobutyrat und dem Hexanikotinsäureester des meso-Inosits [Pharmacokinetics of a combination of magnesium-chlorophenoxy-isobutyrate and meso-inositol hexanicotinate]. Acta Med Austriaca. 1977;4(3):120-4. German. PMID: 930544. 2: Krahling JB, Tolbert NE. Peroxisomal beta-ketothiolase. Arch Biochem Biophys. 1981 Jun;209(1):100-10. doi: 10.1016/0003-9861(81)90261-7. PMID: 7283429. 3: Nieper HA. Capillarographic criteria on the effect of magnesium orotate, EPL substances and clofibrate on the elasticity of blood vessels. Agressologie. 1974;15(1):73-7. PMID: 4440820. 4: Lazarow PB. Rat liver peroxisomes catalyze the beta oxidation of fatty acids. J Biol Chem. 1978 Mar 10;253(5):1522-8. PMID: 627552. 5: Capuzzi DM, Margolis S. Metabolic studies in isolated rat liver cells. I. Lipid synthesis. Lipids. 1971 Aug;6(8):601-8. doi: 10.1007/BF02531143. PMID: 4255318. 6: Maragoudakis ME. On the mode of action of lipid-lowering agents. VI. Inhibition of lipogenesis in rat mammary gland cell culture. J Biol Chem. 1971 Jun 25;246(12):4046-52. PMID: 4327196. 7: Gupta JD, Gruca M, Ablett W. Effect of other drugs and chemicals on the degradation of aspirin in vitro: possible extrapolation to in vivo metabolism of aspirin. Eur J Drug Metab Pharmacokinet. 1979;4(2):103-8. doi: 10.1007/BF03189409. PMID: 488131. 8: Kather H, Simon-Crisan G, Vogt B, Simon B. Effects of clofibrate on the human fat cell adenylate cyclase system. Horm Metab Res. 1977 Jul;9(4):300-4. doi: 10.1055/s-0028-1093517. PMID: 196990. 9: Irsigler K, Flegel U, Kühn P, Schubert H, Iván E, Biro L, Székely L. Verbessert Magnesium-Orotat die Wirkung lipidsenkender Pharmaka [Does magnesium- orotate improve the effect of lipid lowering drugs?]. Int J Clin Pharmacol. 1973 Aug;8(1):85-95. German. PMID: 4727450. 10: Ikemoto T, Endo M. Properties of Ca(2+) release induced by clofibric acid from the sarcoplasmic reticulum of mouse skeletal muscle fibres. Br J Pharmacol. 2001 Oct;134(4):719-28. doi: 10.1038/sj.bjp.0704306. PMID: 11606311; PMCID: PMC1573000.