MedKoo Cat#: 413110 | Name: Clofexamide hydrochloride

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Clofexamide hydrochloride is the salt form of Clofexamide, also known as Amichlophene, an antidepressant that was a component of the drug combination clofezone, the other being the non-steroidal anti-inflammatory drug phenylbutazone. Clofexamide is used to treat joint and muscular pain.

Chemical Structure

Clofexamide hydrochloride
Clofexamide hydrochloride
CAS#3482-74-4 (HCl)

Theoretical Analysis

MedKoo Cat#: 413110

Name: Clofexamide hydrochloride

CAS#: 3482-74-4 (HCl)

Chemical Formula: C14H22Cl2N2O2

Exact Mass: 320.1058

Molecular Weight: 321.24

Elemental Analysis: C, 52.34; H, 6.90; Cl, 22.07; N, 8.72; O, 9.96

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
Synonym
Clofexamide hydrochloride; 246 A.N.P.; EINECS 222-466-6
IUPAC/Chemical Name
2-(4-Chlorophenoxy)-N-(2-(diethylamino)ethyl)acetamide monohydrochloride
InChi Key
FIWBEGJXLDEFDE-UHFFFAOYSA-N
InChi Code
InChI=1S/C14H21ClN2O2.ClH/c1-3-17(4-2)10-9-16-14(18)11-19-13-7-5-12(15)6-8-13;/h5-8H,3-4,9-11H2,1-2H3,(H,16,18);1H
SMILES Code
O=C(NCCN(CC)CC)COC1=CC=C(Cl)C=C1.[H]Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 321.24 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Kigasawa K, Tanaka M, Shimizu H, Saito M. [Determination of clofexamide and its metabolites in plasma by gas chromatography]. Yakugaku Zasshi. 1982 Apr;102(4):343-6. Japanese. PubMed PMID: 7131249. 2: Koudela K, Mráz L. [Assessment and testing of the effect and tolerance of Perclusone Salbe (author's transl)]. Acta Chir Orthop Traumatol Cech. 1981 Aug;48(4):349-53. Czech. PubMed PMID: 6457493. 3: Kruszewska A, Langwiński R. [Preliminary pharmacological investigations of six new p-chlorphenoxyacetic acid derivatives (author's transl)]. Ann Univ Mariae Curie Sklodowska Med. 1979;34:259-68. Polish. PubMed PMID: 122234. 4: Irino O, Tateishi M, Fukawa K. Studies on absorption, biotransformation and excretion of drug. 1. Metabolites of clofexamide in rat. Chem Pharm Bull (Tokyo). 1972 Jan;20(1):47-55. PubMed PMID: 5014546. 5: Reinicke C, Helbing M, Klingenfeld U, Lasaroff I, Wessel G. [Comparative studies on the bioavailability of various drug forms of phenylbutazone and clofezone (Perclusone)]. Pharmazie. 1984 Dec;39(12):824-7. German. PubMed PMID: 6241720.