Clofexamide | Amichlophene | CAS#1223-36-5 (free base) | Antidepressent

MedKoo Cat#: 329106 | Name: Clofexamide

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Clofexamide, also known as Amichlophene, is an antidepressant that was a component of the drug combination clofezone, the other being the non-steroidal anti-inflammatory drug phenylbutazone. Clofexamide is used to treat joint and muscular pain.

Chemical Structure

Clofexamide

CAS#1223-36-5 (free base)

Theoretical Analysis

MedKoo Cat#: 329106

Name: Clofexamide

CAS#: 1223-36-5 (free base)

Chemical Formula: C14H21ClN2O2

Exact Mass: 284.1300

Molecular Weight: 284.78

Elemental Analysis: C, 59.05; H, 7.43; Cl, 12.45; N, 9.84; O, 11.24

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

3482-74-4 (HCl) 1223-36-5 (free base)

Synonym

Clofexamide; ANP 246; ANP-246; ANP246; IEM 455; IEM-455; IEM455; NP 246; NP-246; NP246; Amichlophene

IUPAC/Chemical Name

2-(4-chlorophenoxy)-N-(2-(diethylamino)ethyl)acetamide

InChi Key

UORGKWWJEQDTGX-UHFFFAOYSA-N

InChi Code

InChI=1S/C14H21ClN2O2/c1-3-17(4-2)10-9-16-14(18)11-19-13-7-5-12(15)6-8-13/h5-8H,3-4,9-11H2,1-2H3,(H,16,18)

SMILES Code

O=C(NCCN(CC)CC)COC1=CC=C(Cl)C=C1

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 284.78 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Kigasawa K, Tanaka M, Shimizu H, Saito M. [Determination of clofexamide and its metabolites in plasma by gas chromatography]. Yakugaku Zasshi. 1982 Apr;102(4):343-6. Japanese. PubMed PMID: 7131249. 2: Koudela K, Mráz L. [Assessment and testing of the effect and tolerance of Perclusone Salbe (author's transl)]. Acta Chir Orthop Traumatol Cech. 1981 Aug;48(4):349-53. Czech. PubMed PMID: 6457493. 3: Kruszewska A, Langwiński R. [Preliminary pharmacological investigations of six new p-chlorphenoxyacetic acid derivatives (author's transl)]. Ann Univ Mariae Curie Sklodowska Med. 1979;34:259-68. Polish. PubMed PMID: 122234. 4: Irino O, Tateishi M, Fukawa K. Studies on absorption, biotransformation and excretion of drug. 1. Metabolites of clofexamide in rat. Chem Pharm Bull (Tokyo). 1972 Jan;20(1):47-55. PubMed PMID: 5014546. 5: Reinicke C, Helbing M, Klingenfeld U, Lasaroff I, Wessel G. [Comparative studies on the bioavailability of various drug forms of phenylbutazone and clofezone (Perclusone)]. Pharmazie. 1984 Dec;39(12):824-7. German. PubMed PMID: 6241720.