MedKoo Cat#: 317616 | Name: Diloxanide
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Diloxanide is a luminal amebicide used in the treatment of amebiasis. It is considered the luminal agent of choice for mild intestinal amebiasis or asymptomatic cyst carriers. It can also be added to metronidazole (active drug in luminal and extraintestinal amebiasis) in acute amebic dysentery as well as hepatic abscess (In hepatic abscess it is for the control of cysts in the lumen which may cause relapse).

Chemical Structure

Diloxanide
CAS#579-38-4

Theoretical Analysis

MedKoo Cat#: 317616

Name: Diloxanide

CAS#: 579-38-4

Chemical Formula: C9H9Cl2NO2

Exact Mass: 233.0010

Molecular Weight: 234.08

Elemental Analysis: C, 46.18; H, 3.88; Cl, 30.29; N, 5.98; O, 13.67

Price and Availability

Size Price Availability Quantity
100mg USD 450.00 2 Weeks
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Related CAS #
No Data
Synonym
RD 3803; RD-3803; RD3803; Diloxanide; Diloxanid; Diloxanida; Entamide; Amebamida; Ame-boots;
IUPAC/Chemical Name
2,2-dichloro-N-(4-hydroxyphenyl)-N-methylacetamide
InChi Key
GZZZSOOGQLOEOB-UHFFFAOYSA-N
InChi Code
InChI=1S/C9H9Cl2NO2/c1-12(9(14)8(10)11)6-2-4-7(13)5-3-6/h2-5,8,13H,1H3
SMILES Code
O=C(N(C1=CC=C(O)C=C1)C)C(Cl)Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO, not in water
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Product Data
Biological target:
Diloxanide is an anti-protozoal agent and can be used for the research of asymptomatic-intestinal amebiasis caused by Entamoeba histolytica or some other protozoal infections.
In vitro activity:
TBD
In vivo activity:
TBD
Solvent mg/mL mM comments
Solubility
DMSO 33.3 142.39
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 234.08 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
TBD
In vitro protocol:
TBD
In vivo protocol:
TBD
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