Synonym
Iodipamide sodium; EINECS 220-049-3;
IUPAC/Chemical Name
Benzoic acid, 3,3'-(adipoyldiimino)bis(2,4,6-triiodo-, disodium salt
InChi Key
SIZXNBZGPPPFHM-UHFFFAOYSA-L
InChi Code
InChI=1S/C20H14I6N2O6.2Na/c21-7-5-9(23)17(15(25)13(7)19(31)32)27-11(29)3-1-2-4-12(30)28-18-10(24)6-8(22)14(16(18)26)20(33)34;;/h5-6H,1-4H2,(H,27,29)(H,28,30)(H,31,32)(H,33,34);;/q;2*+1/p-2
SMILES Code
O=C(NC1=C(I)C(C([O-])=O)=C(I)C=C1I)CCCCC(NC2=C(I)C(C([O-])=O)=C(I)C=C2I)=O.[Na+].[Na+]
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
1,183.73
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Feld GK, Loeb PM, Berk RN, Wheeler HO. The choleretic effect of iodipamide. J Clin Invest. 1975 Mar;55(3):528-35. doi: 10.1172/JCI107959. PMID: 1117066; PMCID: PMC301780.
2: Thompson WM, Jones RS, Lang JH, Amberg JR. Effect of iopanoate on the biliary and urinary excretion of iodipamide. Invest Radiol. 1978 Jan-Feb;13(1):79-84. doi: 10.1097/00004424-197801000-00016. PMID: 632052.
3: Burgener FA. Pharmacocholangiography. Rofo. 1978 Feb;128(2):135-7. doi: 10.1055/s-0029-1230810. PMID: 147207.
4: Täfler M, Ziegler K, Frimmer M. Iodipamide uptake by rat liver plasma membrane vesicles enriched in the sinusoidal fraction: evidence for a carrier- mediated transport dependent on membrane potential. Biochim Biophys Acta. 1986 Feb 13;855(1):157-68. doi: 10.1016/0005-2736(86)90200-2. PMID: 3942739.
5: Burgener FA, Fischer HW. The effect of sodium taurocholate on biliary iodipamide excretion in the dog. Gastroenterology. 1976 Sep;71(3):475-8. PMID: 950099.
6: Swanson DP, Dick TJ, Simms SM, Thrall JH. Product selection criteria for intravascular ionic contrast media. Clin Pharm. 1985 Sep-Oct;4(5):527-38. PMID: 3902331.
7: KIMBEL KH, HEINKEL K, BORNER W. Die Ausscheidung des Na-Salzes des Adipinsäure-bis[2, 4, 6-trijod-3-carboxy-anilid] bei der Ratte [Sodium iodipamide excretion in rats]. Arzneimittelforschung. 1956 Apr;6(4):225-6. German. PMID: 13315106.
8: Eil C, Chestnut RY. The effects of radiographic contrast agents and other compounds on the nuclear binding of L-[125I]triiodothyronine in dispersed human skin fibroblasts. J Clin Endocrinol Metab. 1985 Mar;60(3):548-52. doi: 10.1210/jcem-60-3-548. PMID: 2982901.
9: FLEISCHMANN E. Erfahrung mit Bilijodon-Natrium, einem neuen oralen Gallenkontrastmittel [Experience with sodium iodipamide, a new oral contrast medium for cholecystography]. Klin Med Osterr Z Wiss Prakt Med. 1957 May;12(5):209-12. German. PMID: 13439904.
10: Pfister RC, Hutter AM Jr, Newhouse JH, Yoder IC, Travers E. Contrast-medium- induced electrocardiographic abnormalities: comparison of bolus and infusion of methylglucamine iodamide and methylglucamine/sodium diatrizoate. AJR Am J Roentgenol. 1983 Jan;140(1):149-53. doi: 10.2214/ajr.140.1.149. PMID: 6600306.
