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MedKoo Cat#: 412586 | Name: Tolonidine nitrate

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Tolonidine nitrate is the salt form of Tolonidine (free base), an antihypertensive agent. It acts by reducing aortic blood flow and increasing peripheral vascular resistances.

Chemical Structure

Tolonidine nitrate
CAS#57524-15-9 (nitrate)

Theoretical Analysis

MedKoo Cat#: 412586

Name: Tolonidine nitrate

CAS#: 57524-15-9 (nitrate)

Chemical Formula: C10H13ClN4O3

Exact Mass:

Molecular Weight: 272.68

Elemental Analysis: C, 44.05; H, 4.81; Cl, 13.00; N, 20.55; O, 17.60

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
4201-22-3 (free base) 57524-15-9 (nitrate)
Synonym
Tolonidine nitrate; Euctan; CERM10,137; CERM-10,137 CERM 10,137
IUPAC/Chemical Name
1H-Imidazol-2-amine, 4,5-dihydro-N-(2-chloro-4-methylphenyl)-, mononitrate
InChi Key
SEIGDXGATKHXKR-UHFFFAOYSA-N
InChi Code
InChI=1S/C10H12ClN3.HNO3/c1-7-2-3-9(8(11)6-7)14-10-12-4-5-13-10;2-1(3)4/h2-3,6H,4-5H2,1H3,(H2,12,13,14);(H,2,3,4)
SMILES Code
CC1=CC=C(NC2=NCCN2)C(Cl)=C1.O[N+]([O-])=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 272.68 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Cosnier D, Hache J, Labrid C, Streichenberger G. Pharmacological properties of 2-(2-chloro-p-toluidino)-2-imidazoline-nitrate (tolonidine), a new antihypertensive agent. III. Action on the secretions of the digestive tract and on the central nervous system, acute toxicity. Arzneimittelforschung. 1975;25(12):1926-33. PMID: 3186. 2: Cosnier D, Duchene-Marullaz P, Grimal J, Rispat G, Streichenberger G. Pharmacological properties of 2-(2-chloro-p-toluidino)-2-imidazoline-nitrate (Tolonidine), a new antihypertensive agent. I. Action on blood pressure and heart rate. Arzneimittelforschung. 1975 Oct;25(10):1557-61. PMID: 1243037. 3: Cosnier D, Labrid C, Rispat G, Streichenberger G. Pharmacological properties of 2-(2-chloro-p-toluidino)-2-imidazoline-nitrate (tolonidine), a new antihypertensive agent. II. Action on cardiac contraction, circulatory parameters, autonomic receptors and diuresis. Arzneimittelforschung. 1975 Nov;25(11):1802-6. PMID: 1243090. 4: De Sarro GB, Ascioti C, Fersini G, Libri V, Marmo E, Nisticò G. Behavioral and electrocortical effects of tolonidine in rats. Res Commun Chem Pathol Pharmacol. 1986 Dec;54(3):299-312. PMID: 3797809.