Synonym
BI-0314; BI 0314; BI0314;
IUPAC/Chemical Name
N-[3-(piperidin-4-yl)-5-(trifluoromethyl)phenyl]guanidine
InChi Key
SVJLJEMEWHBCNB-UHFFFAOYSA-N
InChi Code
InChI=1S/C13H17F3N4/c14-13(15,16)10-5-9(8-1-3-19-4-2-8)6-11(7-10)20-12(17)18/h5-8,19H,1-4H2,(H4,17,18,20)
SMILES Code
NC(NC1=CC(C(F)(F)F)=CC(C2CCNCC2)=C1)=N
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
Preparing Stock Solutions
The following data is based on the
product
molecular weight
286.30
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
Allosteric Activation of Striatal-Enriched Protein Tyrosine Phosphatase (STEP, PTPN5) by a Fragment-like Molecule
Christofer S. Tautermann, Florian Binder, Frank H. Büttner, Christian Eickmeier, Dennis Fiegen, Ulrike Gross, Marc A. Grundl, Ralf Heilker, Scott Hobson, Stefan Hoerer, Andreas Luippold, Volker Mack, Florian Montel, Stefan Peters, Supriyo Bhattacharya, Nagarajan Vaidehi, Gisela Schnapp, Sven Thamm, and Markus Zeeb
Publication Date (Web): September 12, 2018 (Article)
DOI: 10.1021/acs.jmedchem.8b00857
