MedKoo Cat#: 575201 | Name: AZD-2066 sulfate

Description:

WARNING: This product is for research use only, not for human or veterinary use.

AZD-2066 sulfate is an orally bioavailable and brain penetrant mGlu5 antagonist.

Chemical Structure

AZD-2066 sulfate
AZD-2066 sulfate
CAS#934282-57-2 (sulfate)

Theoretical Analysis

MedKoo Cat#: 575201

Name: AZD-2066 sulfate

CAS#: 934282-57-2 (sulfate)

Chemical Formula: C19H18ClN5O6S

Exact Mass: 479.0666

Molecular Weight: 479.89

Elemental Analysis: C, 47.55; H, 3.78; Cl, 7.39; N, 14.59; O, 20.00; S, 6.68

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
Bulk Inquiry
Synonym
AZD-2066 sulfate; AZD2066 sulfate; AZD 2066 sulfate
IUPAC/Chemical Name
Pyridine, 4-(5-((1R)-1-(5-(3-chlorophenyl)-3-isoxazolyl)ethoxy)-4-methyl-4H-1,2,4-triazol-3-yl)-, sulfate (1:1)
InChi Key
AXINWMMNESJNKJ-UTONKHPSSA-N
InChi Code
InChI=1S/C19H16ClN5O2.H2O4S/c1-12(16-11-17(27-24-16)14-4-3-5-15(20)10-14)26-19-23-22-18(25(19)2)13-6-8-21-9-7-13;1-5(2,3)4/h3-12H,1-2H3;(H2,1,2,3,4)/t12-;/m1./s1
SMILES Code
C[C@@H](Oc1nnc(c2ccncc2)n1C)c3cc(on3)c4cccc(Cl)c4.OS(=O)(=O)O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 479.89 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Jaso BA, Niciu MJ, Iadarola ND, Lally N, Richards EM, Park M, Ballard ED, Nugent AC, Machado-Vieira R, Zarate CA Jr. THERAPEUTIC MODULATION OF GLUTAMATE RECEPTORS IN MAJOR DEPRESSIVE DISORDER. Curr Neuropharmacol. 2016 Mar 21. [Epub ahead of print] PubMed PMID: 26997505. 2: Machado-Vieira R, Henter ID, Zarate CA Jr. New targets for rapid antidepressant action. Prog Neurobiol. 2015 Dec 23. pii: S0301-0082(15)30038-1. doi: 10.1016/j.pneurobio.2015.12.001. [Epub ahead of print] Review. PubMed PMID: 26724279. 3: Dutta A, McKie S, Deakin JF. Ketamine and other potential glutamate antidepressants. Psychiatry Res. 2015 Jan 30;225(1-2):1-13. doi: 10.1016/j.psychres.2014.10.028. Epub 2014 Nov 13. Review. PubMed PMID: 25467702.