Isocorydine | CAS#475-67-2 | Alkaloid

MedKoo Cat#: 596432 | Name: Isocorydine

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Isocorydine is an alkaloid from root tubers of Stephania Kwangsiensis H.S. Lo.

Chemical Structure

Isocorydine

CAS#475-67-2

Theoretical Analysis

MedKoo Cat#: 596432

Name: Isocorydine

CAS#: 475-67-2

Chemical Formula: C20H23NO4

Exact Mass: 341.1627

Molecular Weight: 341.40

Elemental Analysis: C, 70.36; H, 6.79; N, 4.10; O, 18.74

Price and Availability

Size	Price	Availability
10mg	USD 250.00	2 Weeks
25mg	USD 500.00	2 Weeks
50mg	USD 850.00	2 Weeks

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Related CAS #

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Synonym

Isocorydine; Luteanin; d-Isocorydine; NSC 32979; NSC-32979; NSC32979;

IUPAC/Chemical Name

(S)-1,2,10-trimethoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinolin-11-ol

InChi Key

QELDJEKNFOQJOY-ZDUSSCGKSA-N

InChi Code

InChI=1S/C20H23NO4/c1-21-8-7-12-10-15(24-3)20(25-4)18-16(12)13(21)9-11-5-6-14(23-2)19(22)17(11)18/h5-6,10,13,22H,7-9H2,1-4H3/t13-/m0/s1

SMILES Code

OC1=C2C3=C4C(CCN(C)[C@@]4([H])CC2=CC=C1OC)=CC(OC)=C3OC

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 341.40 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Xin A, Zhang Y, Zhang Y, Di D, Liu J. Development of an HPLC-DAD method for the determination of five alkaloids in Stephania yunnanensis Lo and in rat plasma after oral dose of Stephania yunnanensis Lo extracts. Biomed Chromatogr. 2018 May 21:e4292. doi: 10.1002/bmc.4292. [Epub ahead of print] PubMed PMID: 29782649. 2: Fuentes-Barros G, Castro-Saavedra S, Liberona L, Acevedo-Fuentes W, Tirapegui C, Mattar C, Cassels BK. Variation of the alkaloid content of Peumus boldus (boldo). Fitoterapia. 2018 Feb 14. pii: S0367-326X(17)31830-0. doi: 10.1016/j.fitote.2018.02.020. [Epub ahead of print] PubMed PMID: 29454020. 3: Pan JX, Chen G, Li JJ, Zhu QD, Li JJ, Chen ZJ, Yu ZP, Ye LY. Isocorydine suppresses doxorubicin-induced epithelial-mesenchymal transition via inhibition of ERK signaling pathways in hepatocellular carcinoma. Am J Cancer Res. 2018 Jan 1;8(1):154-164. eCollection 2018. PubMed PMID: 29416928; PubMed Central PMCID: PMC5794729. 4: Singh A, Bajpai V, Kumar S, Singh Rawat AK, Kumar B. Analysis of isoquinoline alkaloids from Mahonia leschenaultia and Mahonia napaulensis roots using UHPLC-Orbitrap-MS(n) and UHPLC-QqQ(LIT)-MS/MS. J Pharm Anal. 2017 Apr;7(2):77-86. doi: 10.1016/j.jpha.2016.10.002. Epub 2016 Oct 18. PubMed PMID: 29404021; PubMed Central PMCID: PMC5686872. 5: Yan Q, Li RX, Xin AY, Liu JX, Li WG, Di DL. [Research on anticancer activity of isocorydine and its derivatives]. Zhongguo Zhong Yao Za Zhi. 2017 Aug;42(16):3152-3158. doi: 10.19540/j.cnki.cjcmm.20170512.008. Chinese. PubMed PMID: 29171235. 6: Yan Q, Li R, Xin A, Han Y, Zhang Y, Liu J, Li W, Di D. Design, synthesis, and anticancer properties of isocorydine derivatives. Bioorg Med Chem. 2017 Dec 15;25(24):6542-6553. doi: 10.1016/j.bmc.2017.10.027. Epub 2017 Oct 21. PubMed PMID: 29103873. 7: Zhong SH, Fu YH, Zhou XM, Song XP, Chen GY. [Studies on alkaloids from Fissistigma oldhamii]. Zhongguo Zhong Yao Za Zhi. 2016 Aug;41(15):2838-2842. doi: 10.4268/cjcmm20161516. Chinese. PubMed PMID: 28914026. 8: He SM, Song WL, Cong K, Wang X, Dong Y, Cai J, Zhang JJ, Zhang GH, Yang JL, Yang SC, Fan W. Identification of candidate genes involved in isoquinoline alkaloids biosynthesis in Dactylicapnos scandens by transcriptome analysis. Sci Rep. 2017 Aug 22;7(1):9119. doi: 10.1038/s41598-017-08672-w. PubMed PMID: 28831066; PubMed Central PMCID: PMC5567367. 9: Bakiri A, Hubert J, Reynaud R, Lanthony S, Harakat D, Renault JH, Nuzillard JM. Computer-Aided (13)C NMR Chemical Profiling of Crude Natural Extracts without Fractionation. J Nat Prod. 2017 May 26;80(5):1387-1396. doi: 10.1021/acs.jnatprod.6b01063. Epub 2017 Apr 17. PubMed PMID: 28414230. 10: Liu X, Tian H, Li H, Ge C, Zhao F, Yao M, Li J. Derivate Isocorydine (d-ICD) Suppresses Migration and Invasion of Hepatocellular Carcinoma Cell by Downregulating ITGA1 Expression. Int J Mol Sci. 2017 Feb 27;18(3). pii: E514. doi: 10.3390/ijms18030514. PubMed PMID: 28264467; PubMed Central PMCID: PMC5372530. 11: Dary C, Bun SS, Herbette G, Mabrouki F, Bun H, Kim S, Jabbour F, Hul S, Baghdikian B, Ollivier E. Chemical profiling of the tuber of Stephania cambodica Gagnep. (Menispermaceae) and analytical control by UHPLC-DAD. Nat Prod Res. 2017 Apr;31(7):802-809. doi: 10.1080/14786419.2016.1247077. Epub 2016 Dec 15. PubMed PMID: 27976592. 12: Wang H, Cheng X, Kong S, Yang Z, Wang H, Huang Q, Li J, Chen C, Ma Y. Synthesis and Structure-Activity Relationships of a Series of Aporphine Derivatives with Antiarrhythmic Activities and Acute Toxicity. Molecules. 2016 Nov 28;21(12). pii: E1555. PubMed PMID: 27916812. 13: Zahari A, Ablat A, Omer N, Nafiah MA, Sivasothy Y, Mohamad J, Khan MN, Awang K. Ultraviolet-visible study on acid-base equilibria of aporphine alkaloids with antiplasmodial and antioxidant activities from Alseodaphne corneri and Dehaasia longipedicellata. Sci Rep. 2016 Feb 22;6:21517. doi: 10.1038/srep21517. PubMed PMID: 26898753; PubMed Central PMCID: PMC4761911. 14: Bajpai V, Singh A, Chandra P, Negi MP, Kumar N, Kumar B. Analysis of phytochemical variations in dioecious Tinospora cordifolia stems using HPLC/QTOF MS/MS and UPLC/QqQLIT -MS/MS. Phytochem Anal. 2016 Mar-Apr;27(2):92-9. doi: 10.1002/pca.2601. Epub 2015 Dec 2. PubMed PMID: 26627195. 15: Chen L, Tian H, Li M, Ge C, Zhao F, Zhang L, Li H, Liu J, Wang T, Yao M, Li J. Derivate isocorydine inhibits cell proliferation in hepatocellular carcinoma cell lines by inducing G2/M cell cycle arrest and apoptosis. Tumour Biol. 2016 May;37(5):5951-61. doi: 10.1007/s13277-015-4362-6. Epub 2015 Nov 23. PubMed PMID: 26596832. 16: Chen Y, Yan Q, Zhong M, Zhao Q, Liu J, Di D, Liu J. Study on pharmacokinetics and tissue distribution of the isocorydine derivative (AICD) in rats by HPLC-DAD method. Acta Pharm Sin B. 2015 May;5(3):238-45. doi: 10.1016/j.apsb.2015.03.012. Epub 2015 Apr 16. PubMed PMID: 26579452; PubMed Central PMCID: PMC4629263. 17: Li M, Zhang L, Ge C, Chen L, Fang T, Li H, Tian H, Liu J, Chen T, Jiang G, Xie H, Cui Y, Yao M, Li J. An isocorydine derivative (d-ICD) inhibits drug resistance by downregulating IGF2BP3 expression in hepatocellular carcinoma. Oncotarget. 2015 Sep 22;6(28):25149-60. doi: 10.18632/oncotarget.4438. PubMed PMID: 26327240; PubMed Central PMCID: PMC4694821. 18: Qu YH, Jiang M, Wang LY, Li YC, Wang YN, Guo QL, Li YJ, Lin S. [Aporphine alkaloids from Litsea greenmaniana]. Zhongguo Zhong Yao Za Zhi. 2015 Jan;40(1):94-7. Chinese. PubMed PMID: 25993795. 19: Liu Y, Chen X, Liu J, Di D. Three-phase solvent systems for the comprehensive separation of a wide variety of compounds from Dicranostigma leptopodum by high-speed counter-current chromatography. J Sep Sci. 2015 Jun;38(12):2038-45. doi: 10.1002/jssc.201401466. Epub 2015 Jun 1. PubMed PMID: 25864484. 20: Chen Y, Li M, Liu J, Yan Q, Zhong M, Liu J, Di D, Liu J. Simultaneous determination of the content of isoquinoline alkaloids in Dicranostigma leptopodum (Maxim) Fedde and the effective fractionation of the alkaloids by high-performance liquid chromatography with diode array detection. J Sep Sci. 2015 Jan;38(1):9-17. doi: 10.1002/jssc.201400905. Epub 2014 Nov 19. PubMed PMID: 25330407.