MedKoo Cat#: 341061 | Name: Bufetolol

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Bufetolol is a beta-adrenoceptor antagonist.

Chemical Structure

Bufetolol
Bufetolol
CAS#53684-49-4

Theoretical Analysis

MedKoo Cat#: 341061

Name: Bufetolol

CAS#: 53684-49-4

Chemical Formula: C18H29NO4

Exact Mass: 323.2097

Molecular Weight: 323.43

Elemental Analysis: C, 66.84; H, 9.04; N, 4.33; O, 19.79

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Bufetolol
IUPAC/Chemical Name
2-Propanol, 1-(1,1-(dimethylethyl)amino)-3-(2-((tetrahydro-2-furanyl)methoxy)phenoxy)-
InChi Key
AKLNLVOZXMQGSI-CABCVRRESA-N
InChi Code
InChI=1S/C18H29NO4/c1-18(2,3)19-11-14(20)12-22-16-8-4-5-9-17(16)23-13-15-7-6-10-21-15/h4-5,8-9,14-15,19-20H,6-7,10-13H2,1-3H3/t14-,15+/m1/s1
SMILES Code
c1ccc(OC[C@@H](CNC(C)(C)C)O)c(OC[C@@H]2CCCO2)c1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 323.43 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Kudo S, Nozawa Y. Different effects of various beta-adrenoceptor antagonists on adenylate cyclase, guanylate cyclase and calmodulin-dependent phosphodiesterase in heart. Biochem Pharmacol. 1985 May 15;34(10):1659-64. PubMed PMID: 2860906. 2: Kimura T, Satoh S. Presynaptic inhibition by serotonin of cardiac sympathetic transmission in dogs. Clin Exp Pharmacol Physiol. 1983 Sep-Oct;10(5):535-42. PubMed PMID: 6315283. 3: Sada H, Harada S, Ban T. Effects of beta-adrenoceptor blocking agents of N-tertiary butyl derivatives on maximum upstroke velocity of action potential in guinea-pig papillary muscles. Naunyn Schmiedebergs Arch Pharmacol. 1983 Sep;324(1):50-7. PubMed PMID: 6138715. 4: Tsukiyama H, Otsuka K, Horii M, Yoshii Y, Hatori Y, Nakamura Y, Nemoto E, Yamato T, Sakai T, Yamamoto Y. Possible significance of the pharmacological differentiation of beta-blocking agents in hemodynamic effects in essential hypertension. Jpn Circ J. 1983 Mar;47(3):313-22. PubMed PMID: 6132016. 5: Murakami K, Kasama T, Hayashi R, Tsushima M, Nishioheda Y, Koh H, Nambu S, Ikeda M. Myxoedema coma induced by beta-adrenoreceptor-blocking agent. Br Med J (Clin Res Ed). 1982 Aug 21;285(6341):543-4. PubMed PMID: 6125234; PubMed Central PMCID: PMC1499068. 6: Ozawa H, Matsubara T, Chen CS. Analysis of hypotensive mechanisms of pindolol, a beta-adrenoceptor blocking drugs in rats. Jpn J Pharmacol. 1977 Apr;27(2):295-302. PubMed PMID: 18631. 7: Inui J, Miura Y, Imamura H. [Simple on-line digital determination of the cardiac action potential and its application]. Nihon Yakurigaku Zasshi. 1977 Mar;73(2):143-50. Japanese. PubMed PMID: 18384. 8: Inui J, Imamura H. Beta-adrenoceptor blocking and electrophysiological effects of bufetolol in the guinea pig atria. Eur J Pharmacol. 1977 Feb 7;41(3):251-60. PubMed PMID: 14011. 9: Inui J, Imamura H. Effects of bufetolol and propranolol on active and passive membrane properties of dog papillary muscle. Jpn J Pharmacol. 1976 Dec;26(6):639-47. PubMed PMID: 15153. 10: Inui J, Imamura H. Restoration by histamine of the calcium-dependent electrical and mechanical response in the guinea-pig papillary muscle partially depolarized by potassium. Naunyn Schmiedebergs Arch Pharmacol. 1976 Sep;294(3):261-9. PubMed PMID: 12480. 11: Tsukiyama H, Otsuka K, Miyamoto K, Hashimoto M, Yasutake S. Hemodynamic effects of beta-adrenergic blockade with pindolol, oxprenolol, propranolol and bufetolol hydrochloride in essential hypertension. Jpn Circ J. 1976 Jun;40(6):655-64. PubMed PMID: 7688. 12: Ikegami K, Imamura H. [Effects of bufetolol on rat heart and liver adenyl cyclase activities]. Yakugaku Zasshi. 1976 May;96(5):614-20. Japanese. PubMed PMID: 9502.