MedKoo Cat#: 463504 | Name: CB096
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

CB096 is a novel inhibitor of RAN translation. specifically binds to a repeating 1 × 1 GG internal loop structure, 5'CGG/3'GGC, that is formed when r(G4C2)exp folds, also acting as a potent vasorelaxant agent, showing antihypertensive effect.

Chemical Structure

CB096
CB096
CAS#108883-90-5

Theoretical Analysis

MedKoo Cat#: 463504

Name: CB096

CAS#: 108883-90-5

Chemical Formula: C14H11N3O4

Exact Mass: 285.0750

Molecular Weight: 285.26

Elemental Analysis: C, 58.95; H, 3.89; N, 14.73; O, 22.43

Price and Availability

Size Price Availability Quantity
10mg USD 325.00 2 Weeks
50mg USD 850.00 2 Weeks
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Related CAS #
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Synonym
CB096; CB 096; CB-096;
IUPAC/Chemical Name
2-methoxy-4-(5-nitro-1H-benzo[d]imidazol-2-yl)phenol
InChi Key
LSNPOGOZVAHETR-UHFFFAOYSA-N
InChi Code
InChI=1S/C14H11N3O4/c1-21-13-6-8(2-5-12(13)18)14-15-10-4-3-9(17(19)20)7-11(10)16-14/h2-7,18H,1H3,(H,15,16)
SMILES Code
OC1=CC=C(C2=NC3=CC([N+]([O-])=O)=CC=C3N2)C=C1OC
Appearance
Solid powder
Purity
>95% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 285.26 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Ursu A, Wang KW, Bush JA, Choudhary S, Chen JL, Baisden JT, Zhang YJ, Gendron TF, Petrucelli L, Yildirim I, Disney MD. Structural Features of Small Molecules Targeting the RNA Repeat Expansion That Causes Genetically Defined ALS/FTD. ACS Chem Biol. 2020 Nov 16. doi: 10.1021/acschembio.0c00049. Epub ahead of print. PMID: 33196168.