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MedKoo Cat#: 13022 | Name: GPS167

Description:

WARNING: This product is for research use only, not for human or veterinary use.

GPS167 is an inhibitor that targets SRSF10, reducing the production of BCLAF1-L, the excess of which leads to metastatic colorectal cancer.

Chemical Structure

GPS167
GPS167
CAS#N/A

Theoretical Analysis

MedKoo Cat#: 13022

Name: GPS167

CAS#: N/A

Chemical Formula: C17H13N5OS

Exact Mass: 335.0841

Molecular Weight: 335.39

Elemental Analysis: C, 60.88; H, 3.91; N, 20.88; O, 4.77; S, 9.56

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
GPS167; GPS 167; GPS-167; NSC-805576; NSC805576; NSC 805576
IUPAC/Chemical Name
N-(1H-indazol-5-yl)-2-(phenylamino)thiazole-4-carboxamide
InChi Key
CYVGSDYVNUNREA-UHFFFAOYSA-N
InChi Code
InChI=1S/C17H13N5OS/c23-16(19-13-6-7-14-11(8-13)9-18-22-14)15-10-24-17(21-15)20-12-4-2-1-3-5-12/h1-10H,(H,18,22)(H,19,23)(H,20,21)
SMILES Code
O=C(C1=CSC(NC2=CC=CC=C2)=N1)NC3=CC4=C(NN=C4)C=C3
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 335.39 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1. Sohail M, Shkreta L, Toutant J, Rabea S, Babeu JP, Huard C, Coulombe-Huntington J, Delannoy A, Placet M, Geha S, Gendron FP, Boudreau F, Tyers M, Grierson DS, Chabot B. A novel class of inhibitors that target SRSF10 and promote p53-mediated cytotoxicity on human colorectal cancer cells. NAR Cancer. 2021 May 25;3(2):zcab019. doi: 10.1093/narcan/zcab019. PMID: 34316707; PMCID: PMC8210162.