MedKoo Cat#: 150022 | Name: GPX4 inhibitor C18

Description:

WARNING: This product is for research use only, not for human or veterinary use.

GPX4 inhibitor C18 is a GPX4 Inhibitor. GPX4 is a target to induce ferroptosis for the treatment of triple-negative breast cancer. C18 exhibited an outstanding potency of tumor growth inhibition without toxicity.

Chemical Structure

GPX4 inhibitor C18
GPX4 inhibitor C18
CAS# 2922824-09-5

Theoretical Analysis

MedKoo Cat#: 150022

Name: GPX4 inhibitor C18

CAS#: 2922824-09-5

Chemical Formula: C18H17ClFNO5

Exact Mass: 381.0779

Molecular Weight: 381.78

Elemental Analysis: C, 56.63; H, 4.49; Cl, 9.29; F, 4.98; N, 3.67; O, 20.95

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
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Synonym
GPX4 inhibitor C18;
IUPAC/Chemical Name
5-[(3S)-3-Hydroxy-4-phenyl-1-buten-1-yl]1-[6-(2H-tetrazol-5R-yl)hexyl]-2-pyrrolidinone
InChi Key
HKXSBJJCHBFTMB-UHFFFAOYSA-N
InChi Code
1S/C18H17ClFNO5/c1-23-15-8-12(9-16(24-2)18(15)20)21(17(22)10-19)11-3-4-13-14(7-11)26-6-5-25-13/h3-4,7-9H,5-6,10H2,1-2H3
SMILES Code
O=C(N(C1=CC=C2OCCOC2=C1)C3=CC(OC)=C(F)C(OC)=C3)CCl
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 381.78 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Chen T, Leng J, Tan J, Zhao Y, Xie S, Zhao S, Yan X, Zhu L, Luo J, Kong L, Yin Y. Discovery of Novel Potent Covalent Glutathione Peroxidase 4 Inhibitors as Highly Selective Ferroptosis Inducers for the Treatment of Triple-Negative Breast Cancer. J Med Chem. 2023 Jul 27;66(14):10036-10059. doi: 10.1021/acs.jmedchem.3c00967. Epub 2023 Jul 15. PMID: 37452764.