MedKoo Cat#: 128759 | Name: GPX4 9i
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

GPX4 9i is a ferroptosis inducer. It is cytotoxic to HT-1080 cells (IC50 = 0.007 µM), an effect that can be reversed by the ferroptosis inhibitor ferrostatin-1

Chemical Structure

GPX4 9i
GPX4 9i
CAS#3035800-33-7

Theoretical Analysis

MedKoo Cat#: 128759

Name: GPX4 9i

CAS#: 3035800-33-7

Chemical Formula: C29H24N4O3S2

Exact Mass: 540.1290

Molecular Weight: 540.66

Elemental Analysis: C, 64.43; H, 4.47; N, 10.36; O, 8.88; S, 11.86

Price and Availability

Size Price Availability Quantity
1mg USD 350.00 2 Weeks
5mg USD 650.00 2 Weeks
10mg USD 950.00 2 Weeks
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Related CAS #
No Data
Synonym
GPX4 9i; GPX4-9i; GPX49i
IUPAC/Chemical Name
N-(1-(benzo[b]thiophen-3-yl)-2-(tert-butylamino)-2-oxoethyl)-2-ethynyl-N-(4-(oxazol-5-yl)phenyl)thiazole-4-carboxamide
InChi Key
NBLAYHIFDLIFHK-UHFFFAOYSA-N
InChi Code
InChI=1S/C29H24N4O3S2/c1-5-25-31-22(16-38-25)28(35)33(19-12-10-18(11-13-19)23-14-30-17-36-23)26(27(34)32-29(2,3)4)21-15-37-24-9-7-6-8-20(21)24/h1,6-17,26H,2-4H3,(H,32,34)
SMILES Code
O=C(N(C(C1=CSC2=CC=CC=C21)C(NC(C)(C)C)=O)C3=CC=C(C4=CN=CO4)C=C3)C5=CSC(C#C)=N5
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 540.66 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1. Gu, S., Yang, G., Bian, H., et al. Development of a highly selective ferroptosis inducer targeting GPX4 with 2-ethynylthiazole-4-carboxamide as electrophilic warhead. J. Med. Chem. 68(3), 3309-3323 (2025).