MedKoo Biosciences, Inc.
Tel:   +1-919-636-5577    Fax:   +1-919-980-4831    Email:   sales@medkoo.com
Search
Login Register
Search
MedKoo Cat#: 412551 | Name: Celiprolol hydrochloride
Featured

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Celiprolol hydrochloride is a cardioselective beta-1-adrenergic antagonist that may act as a partial agonist at some adrenergic sites.

Chemical Structure

Celiprolol hydrochloride
CAS#57470-78-7 (HCl)

Theoretical Analysis

MedKoo Cat#: 412551

Name: Celiprolol hydrochloride

CAS#: 57470-78-7 (HCl)

Chemical Formula: C20H34ClN3O4

Exact Mass: 0.0000

Molecular Weight: 415.96

Elemental Analysis: C, 57.75; H, 8.24; Cl, 8.52; N, 10.10; O, 15.39

Price and Availability

Size Price Availability Quantity
10mg USD 350.00 2 Weeks
50mg USD 950.00 2 Weeks
Bulk Inquiry
Buy Now
Add to Cart
Related CAS #
56980-93-9 (free base) 57470-78-7 (HCl)
Synonym
Celiprolol hydrochloride; Celiprolol HCl; St1396; St-1396 St 1396; Corliprol; NSC 324509; NSC324509; NSC-324509;
IUPAC/Chemical Name
3-(3-acetyl-4-(3-(tert-butylamino)-2-hydroxypropoxy)phenyl)-1,1-diethylurea hydrochloride
InChi Key
VKJHTUVLJYWAEY-UHFFFAOYSA-N
InChi Code
InChI=1S/C20H33N3O4.ClH/c1-7-23(8-2)19(26)22-15-9-10-18(17(11-15)14(3)24)27-13-16(25)12-21-20(4,5)6;/h9-11,16,21,25H,7-8,12-13H2,1-6H3,(H,22,26);1H
SMILES Code
O=C(NC1=CC=C(OCC(O)CNC(C)(C)C)C(C(C)=O)=C1)N(CC)CC.[H]Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 415.96 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Taylor SH. Celiprolol in hypertension. Am Heart J. 1988 Nov;116(5 Pt 2):1426-34. doi: 10.1016/0002-8703(88)90135-4. PMID: 2903654. 2: Dickinson R, Horobin J. Celiprolol. Lancet. 1992 Apr 11;339(8798):940. doi: 10.1016/0140-6736(92)90990-k. PMID: 1348344. 3: Thom S, Hughes A, Schachter M, Sever P. Celiprolol. Lancet. 1992 Jan 25;339(8787):247. doi: 10.1016/0140-6736(92)90051-4. PMID: 1346201. 4: Celiprolol--a better beta blocker? Drug Ther Bull. 1992 Apr 27;30(9):35-6. PMID: 1350530. 5: Riddell JG, Shanks RG, Brogden RN. Celiprolol. A preliminary review of its pharmacodynamic and pharmacokinetic properties and its therapeutic use in hypertension and angina pectoris. Drugs. 1987 Oct;34(4):438-58. doi: 10.2165/00003495-198734040-00002. PMID: 2890513. 6: Dunn CJ, Spencer CM. Celiprolol. An evaluation of its pharmacological properties and clinical efficacy in the management of hypertension and angina pectoris. Drugs Aging. 1995 Nov;7(5):394-411. doi: 10.2165/00002512-199507050-00006. PMID: 8573993. 7: Milne RJ, Buckley MM. Celiprolol. An updated review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in cardiovascular disease. Drugs. 1991 Jun;41(6):941-69. doi: 10.2165/00003495-199141060-00009. Erratum in: Drugs 1991 Oct;42(4):639. Erratum in: Drugs 1992 Feb;43(2):145. PMID: 1715268. 8: Lombard JN, Bonnotte B, Maynadie M, Foucher P, Reybet Degat O, Jeannin L, Camus P. Celiprolol pneumonitis. Eur Respir J. 1993 Apr;6(4):588-91. PMID: 8098286. 9: Baderkhan H, Wanhainen A, Stenborg A, Stattin EL, Björck M. Celiprolol Treatment in Patients with Vascular Ehlers-Danlos Syndrome. Eur J Vasc Endovasc Surg. 2021 Feb;61(2):326-331. doi: 10.1016/j.ejvs.2020.10.020. Epub 2020 Nov 20. PMID: 33223285. 10: Soberman JE, Frishman WH. Celiprolol in angina pectoris. Am Heart J. 1988 Nov;116(5 Pt 2):1422-5. doi: 10.1016/0002-8703(88)90134-2. PMID: 2903653. 11: Lamon KD. Safety profile of celiprolol. Am Heart J. 1988 Nov;116(5 Pt 2):1438-40. doi: 10.1016/0002-8703(88)90138-x. PMID: 2903657. 12: Nawarskas JJ, Cheng-Lai A, Frishman WH. Celiprolol: A Unique Selective Adrenoceptor Modulator. Cardiol Rev. 2017 Sep/Oct;25(5):247-253. doi: 10.1097/CRD.0000000000000159. PMID: 28742547; PMCID: PMC5549637. 13: Gorlin R. Celiprolol: introduction. Am Heart J. 1988 Nov;116(5 Pt 2):1383-4. doi: 10.1016/0002-8703(88)90127-5. PMID: 2903646. 14: Lamon KD. Evaluation of celiprolol, a new cardioselective beta 1-adrenergic blocker with vasodilating properties, in the treatment of mild to moderate hypertension in the elderly. Cardiovasc Drugs Ther. 1991 Jan;4 Suppl 6:1291-5. doi: 10.1007/BF00114236. PMID: 1672605. 15: Hunninghake DB. Effects of celiprolol and other antihypertensive agents on serum lipids and lipoproteins. Am Heart J. 1991 Feb;121(2 Pt 2):696-701. doi: 10.1016/0002-8703(91)90449-r. PMID: 1671189. 16: Kendall MJ, Rajman I. A risk-benefit assessment of celiprolol in the treatment of cardiovascular disease. Drug Saf. 1994 Mar;10(3):220-32. doi: 10.2165/00002018-199410030-00004. PMID: 7913813. 17: Parati G, Ravogli A, Bragato R, Omboni S, Mutti E, Mancia G. Clinical and hemodynamic effects of celiprolol in essential hypertension. J Cardiovasc Pharmacol. 1989;14 Suppl 7:S14-21. PMID: 2481785. 18: Galende I, Suárez JR, Azanza JR, Honorato J. Celiprolol [Celiprolol]. Rev Med Univ Navarra. 1988 Oct-Dec;32(4):229-32. Spanish. PMID: 2908736. 19: Pruss TP, Khandwala A, Wolf PS, Grebow P, Wong L. Celiprolol: a new beta adrenoceptor antagonist with novel ancillary properties. J Cardiovasc Pharmacol. 1986;8 Suppl 4:S29-32. PMID: 2427849. 20: Dubacher N, Münger J, Gorosabel MC, Crabb J, Ksiazek AA, Caspar SM, Bakker ENTP, van Bavel E, Ziegler U, Carrel T, Steinmann B, Zeisberger S, Meienberg J, Matyas G. Celiprolol but not losartan improves the biomechanical integrity of the aorta in a mouse model of vascular Ehlers-Danlos syndrome. Cardiovasc Res. 2020 Feb 1;116(2):457-465. doi: 10.1093/cvr/cvz095. PMID: 31056650.

View History

Diclazuril potassium

Diclazuril potassium