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MedKoo Cat#: 598157 | Name: LHRH, Ala(6)-

Description:

WARNING: This product is for research use only, not for human or veterinary use.

LHRH, Ala(6)- is a synthetic luteinizing hormone-releasing hormone agonist.

Chemical Structure

LHRH, Ala(6)-
LHRH, Ala(6)-
CAS#51278-35-4

Theoretical Analysis

MedKoo Cat#: 598157

Name: LHRH, Ala(6)-

CAS#: 51278-35-4

Chemical Formula: C56H77N17O13

Exact Mass: 1195.5887

Molecular Weight: 1196.33

Elemental Analysis: C, 56.22; H, 6.49; N, 19.90; O, 17.39

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
LHRH, Ala(6)-; L1868; L 1868; L-1868;
IUPAC/Chemical Name
(S)-N-(2-amino-2-oxoethyl)-1-(((S)-5-oxopyrrolidine-2-carbonyl)-L-histidyl-L-tryptophyl-L-seryl-L-tyrosyl-L-alanyl-L-leucyl-L-arginyl)pyrrolidine-2-carboxamide
InChi Key
SESQMDHICVIJCF-AVNYGLLKSA-N
InChi Code
1S/C56H77N17O13/c1-29(2)20-39(50(81)67-38(10-6-18-61-56(58)59)55(86)73-19-7-11-44(73)54(85)63-26-45(57)76)68-47(78)30(3)65-49(80)40(21-31-12-14-34(75)15-13-31)69-53(84)43(27-74)72-51(82)41(22-32-24-62-36-9-5-4-8-35(32)36)70-52(83)42(23-33-25-60-28-64-33)71-48(79)37-16-17-46(77)66-37/h4-5,8-9,12-15,24-25,28-30,37-44,62,74-75H,6-7,10-11,16-23,26-27H2,1-3H3,(H2,57,76)(H,60,64)(H,63,85)(H,65,80)(H,66,77)(H,67,81)(H,68,78)(H,69,84)(H,70,83)(H,71,79)(H,72,82)(H4,58,59,61)/t30-,37-,38-,39-,40-,41-,42-,43-,44-/m0/s1
SMILES Code
C[C@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H]1CCC(N1)=O)=O)Cc2[nH]cnc2)=O)Cc3c4ccccc4[nH]c3)=O)CO)=O)Cc5ccc(O)cc5)=O)C(N[C@H](C(N[C@H](C(N6CCC[C@H]6C(NCC(N)=O)=O)=O)CCCNC(N)=N)=O)CC(C)C)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 1,196.33 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Saidapur SK, Pramoda S. Effect of (d-Ala6) LHRH on hypophyseal gonadotrophs and ovary of adult frog, Rana tigrina (Daud.) during post-breeding regression phase. Indian J Exp Biol. 1993 May;31(5):406-9. PubMed PMID: 8359846. 2: Yang X, Ma JK, Malanga CJ, Rojanasakul Y. Characterization of proteolytic activities of pulmonary alveolar epithelium. Int J Pharm. 2000 Feb 15;195(1-2):93-101. PubMed PMID: 10675687. 3: Dimino MJ, Snitzer J, Brown KM. Inositol phosphates accumulation in ovarian granulosa after stimulation by luteinizing hormone. Biol Reprod. 1987 Dec;37(5):1129-34. PubMed PMID: 2832007. 4: Weil C, Hansen P, Hyam D, Le Gac F, Breton B, Crim LW. Use of pituitary cells in primary culture to study the regulation of gonadotropin hormone (GtH) secretion in rainbow trout: setting up and validating the system as assessed by its responsiveness to mammalian and salmon gonadotropin releasing hormone. Gen Comp Endocrinol. 1986 May;62(2):202-9. PubMed PMID: 3536657. 5: Han K, Park JS, Chung YB, Lee MJ, Moon DC, Robinson JR. Identification of enzymatic degradation products of luteinizing hormone releasing hormone (LHRH)/[D-Ala6] LHRH in rabbit mucosal homogenates. Pharm Res. 1995 Oct;12(10):1539-44. PubMed PMID: 8584496. 6: Goodwin AE, Grizzle JM. Granulomatous inflammation and monstrous giant cells in response to intraperitoneal hormone implants in channel catfish (Ictalurus punctatus). J Comp Pathol. 1991 Feb;104(2):147-60. PubMed PMID: 1865025. 7: Hashizume T, Yang WH, Clay CM, Nett TM. Internalization rates of murine and ovine gonadotropin-releasing hormone receptors. Biol Reprod. 2001 Mar;64(3):898-903. PubMed PMID: 11207206. 8: Ng'wena AG, Patel NB, Wango EO. Plasma luteinizing hormone levels in response to gonadotropin-releasing hormone agonist and clonidine in Trypanosoma congolense-infected female goats. Brain Res Bull. 1997;44(5):591-5. PubMed PMID: 9365802. 9: Lu RK. [Clinical study on LRH-A contraception by luteolysis]. Zhonghua Fu Chan Ke Za Zhi. 1989 Jan;24(1):26-8, 58. Chinese. PubMed PMID: 2667912. 10: de la Llosa-Hermier MP, Zongazo MA, Martal J, Hermier C. Lack of short-term modulation of in vitro placental progesterone secretion in sheep. Placenta. 1988 Nov-Dec;9(6):623-31. PubMed PMID: 3070536. 11: Emons G, Hoffmann HG, Brack C, Ortmann O, Sturm R, Ball P, Knuppen R. Modulation of gonadotropin-releasing hormone receptor concentration in cultured female rat pituitary cells by estradiol treatment. J Steroid Biochem. 1988 Nov;31(5):751-6. PubMed PMID: 2848982.