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MedKoo Cat#: 592360 | Name: Dinactin
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Dinactin is a macrotetrolide antibiotic and inhibits T-cell proliferation.

Chemical Structure

Dinactin
Dinactin
CAS#20261-85-2

Theoretical Analysis

MedKoo Cat#: 592360

Name: Dinactin

CAS#: 20261-85-2

Chemical Formula: C42H68O12

Exact Mass: 764.4711

Molecular Weight: 764.99

Elemental Analysis: C, 65.94; H, 8.96; O, 25.10

Price and Availability

Size Price Availability Quantity
1mg USD 685.00 2 Weeks
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Synonym
Dinactin; Antibiotic 170t; NSC 63925; NSC-63925; NSC63925
IUPAC/Chemical Name
(1R,2R,5R,7R,10S,11S,14S,16S,19R,20R,23R,25R,28S,29S,32S,34S)-5,23-diethyl-2,11,14,20,29,32-hexamethyl-4,13,22,31,37,38,39,40-octaoxapentacyclo[32.2.1.17,10.116,19.125,28]tetracontane-3,12,21,30-tetrone
InChi Key
ZBDGIMZKOJALMU-HXUSMMTHSA-N
InChi Code
InChI=1S/C42H68O12/c1-9-29-21-33-13-17-35(51-33)25(5)39(43)47-24(4)20-32-12-16-38(50-32)28(8)42(46)54-30(10-2)22-34-14-18-36(52-34)26(6)40(44)48-23(3)19-31-11-15-37(49-31)27(7)41(45)53-29/h23-38H,9-22H2,1-8H3/t23-,24-,25-,26-,27+,28+,29+,30+,31-,32-,33+,34+,35-,36-,37+,38+/m0/s1
SMILES Code
O=C(O[C@H](CC)C[C@]1([H])O[C@@]([C@@H]2C)([H])CC1)[C@H](C)[C@@]3([H])CC[C@](C[C@H](C)OC([C@H]([C@@]4([H])O[C@](C[C@H](OC([C@H](C)[C@]5([H])O[C@](CC5)([H])C[C@H](C)OC2=O)=O)CC)([H])CC4)C)=O)([H])O3
Appearance
Solid powder
Purity
>95% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info
Product Data
Product Data
Instruction
View handling instruction
Biological target:
Dinactin shows marked inhibition of HCT-116 cell growth with an IC50 of 1.1 µM.
In vitro activity:
Dinactin exhibited marked anti-tumor potential with IC50 of 1.1- 9.7μM in various human cancerous cell lines and showed least cytotoxicity (IC50∼80μM) in normal cells (HEK-293). Dinactin inhabited cellular proliferation in cancer cells, reduced their clonogenic survival as validated by clonogenic assay and also inhabited cell migration and invasion characteristics in colon cancer (HCT-116) cells. Reference: Microbiol Res. 2018 Mar;207:196-202. https://pubmed.ncbi.nlm.nih.gov/29458855/
In vivo activity:
TBD

Preparing Stock Solutions

The following data is based on the product molecular weight 764.99 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
1. Zhang K, Gu L, Zhang Y, Liu Z, Li X. Dinactin from a new producer, Streptomyces badius gz-8, and its antifungal activity against the rubber anthracnose fungus Colletotrichum gloeosporioides. Microbiol Res. 2020 Nov;240:126548. doi: 10.1016/j.micres.2020.126548. Epub 2020 Jul 6. PMID: 32653809. 2. Hussain A, Rather MA, Dar MS, Dangroo NA, Aga MA, Qayum A, Shah AM, Ahmad Z, Dar MJ, Hassan QP. Streptomyces puniceus strain AS13., Production, characterization and evaluation of bioactive metabolites: A new face of dinactin as an antitumor antibiotic. Microbiol Res. 2018 Mar;207:196-202. doi: 10.1016/j.micres.2017.12.004. Epub 2017 Dec 8. Erratum in: Microbiol Res. 2018 Dec;217:108. PMID: 29458855.
In vitro protocol:
1. Zhang K, Gu L, Zhang Y, Liu Z, Li X. Dinactin from a new producer, Streptomyces badius gz-8, and its antifungal activity against the rubber anthracnose fungus Colletotrichum gloeosporioides. Microbiol Res. 2020 Nov;240:126548. doi: 10.1016/j.micres.2020.126548. Epub 2020 Jul 6. PMID: 32653809. 2. Hussain A, Rather MA, Dar MS, Dangroo NA, Aga MA, Qayum A, Shah AM, Ahmad Z, Dar MJ, Hassan QP. Streptomyces puniceus strain AS13., Production, characterization and evaluation of bioactive metabolites: A new face of dinactin as an antitumor antibiotic. Microbiol Res. 2018 Mar;207:196-202. doi: 10.1016/j.micres.2017.12.004. Epub 2017 Dec 8. Erratum in: Microbiol Res. 2018 Dec;217:108. PMID: 29458855.
In vivo protocol:
TBD
1: Hussain A, Rather MA, Dar MS, Dangroo NA, Aga MA, Qayum A, Shah AM, Ahmad Z, Dar MJ, Hassan QP. Streptomyces puniceus strain AS13., Production, characterization and evaluation of bioactive metabolites: A new face of dinactin as an antitumor antibiotic. Microbiol Res. 2018 Mar;207:196-202. doi: 10.1016/j.micres.2017.12.004. Epub 2017 Dec 8. PubMed PMID: 29458855. 2: Umland SP, Shah H, Jakway JP, Shortall J, Razac S, Garlisi CG, Falcone A, Kung TT, Stelts D, Hegde V, Patel M, Motasim Billah M, Egan RW. Effects of cyclosporin A and dinactin on T-cell proliferation, interleukin-5 production, and murine pulmonary inflammation. Am J Respir Cell Mol Biol. 1999 Mar;20(3):481-92. PubMed PMID: 10030847. 3: Tanouchi Y, Shichi H. Immunosuppressive effects of polynactins (tetranactin, trinactin and dinactin) on experimental autoimmune uveoretinitis in rats. Jpn J Ophthalmol. 1987;31(2):218-29. PubMed PMID: 3499534. 4: Asher IM, Phillies GD, Kim BJ, Stanley HE. Ion complexation in nonactin, monactin, and dinactin: a Raman spectroscopic study. Biopolymers. 1977 Jan;16(1):157-85. PubMed PMID: 576586. 5: Haneda M, Nawata Y, Hayashi T, Ando K. Tetranactin, a new miticidal antibiotic. VI. Determination of dinactin, trinactin and tetranactin in their mixtures by NMR spectroscopy. J Antibiot (Tokyo). 1974 Jul;27(7):555-7. PubMed PMID: 4457535. 6: Rensing L. Effects of 2,4-dinitrophenol and dinactin on heat-sensitive and ecdysone-specific puffs of Drosophila salivary gland chromosomes in vitro. Cell Differ. 1973 Oct;2(4):221-8. PubMed PMID: 4209536. 7: Bachofen R, Specht-Jürgensen I. [The action of dinactin on cyclic photophosphorylation, on the light-triggered ATP-Pi exchange reaction and on the light-induced proton transport in chloroplasts]. Planta. 1969 Mar;90(1):66-79. doi: 10.1007/BF00389297. German. PubMed PMID: 24500673. 8: Graven SN, Lardy HA, Rutter A. Antibiotics as tools for metabolic studies. VI. Damped oscillatory swelling of mitochondria induced by nonactin, monactin, dinactin, and trinactin. Biochemistry. 1966 May;5(5):1735-42. PubMed PMID: 5962273. 9: Graven SN, Lardy HA, Johnson D, Rutter A. Antibiotics as tools for metabolic studies. V. Effect of nonactin, monactin, dinactin, and trinactin on oxidative phosphorylation and adenosine triphosphatase induction. Biochemistry. 1966 May;5(5):1729-35. PubMed PMID: 4225380. 10: MEYERS E, PANSY FE, PERLMAN D, SMITH DA, WEISENBORN FL. THE IN VITRO ACTIVITY OF NONACTIN AND ITS HOMOLOGS: MONACTIN, DINACTIN AND TRINACTIN. J Antibiot (Tokyo). 1965 May;18:128-9. PubMed PMID: 14336167.