Ceftazidime is a third-generation cephalosporin antibiotic with potent activity against a broad range of Gram-negative bacteria, including Pseudomonas aeruginosa. Its antibacterial action is mediated by inhibition of bacterial cell wall synthesis via high affinity binding to penicillin-binding proteins (PBPs). Ceftazidime exhibits minimum inhibitory concentrations (MICs) typically ranging from 0.25 to 8 µg/mL for susceptible strains of Escherichia coli, Klebsiella pneumoniae, and P. aeruginosa, with an MIC90 of ~4 µg/mL against many Enterobacteriaceae. It is ineffective against most Gram-positive bacteria and anaerobes. Resistance is primarily mediated by extended-spectrum β-lactamases (ESBLs) and AmpC β-lactamase overexpression. Ceftazidime has been widely used for serious infections such as nosocomial pneumonia, bacteremia, and urinary tract infections, often in hospitalized settings.
MedKoo Cat#: 412543
Name: Ceftazidime HCl
CAS#: 73547-70-3 (2HCl)
Chemical Formula: C22H24Cl2N6O7S2
Exact Mass: 0.0000
Molecular Weight: 619.49
Elemental Analysis: C, 42.65; H, 3.91; Cl, 11.44; N, 13.57; O, 18.08; S, 10.35
The following data is based on the product molecular weight 619.49 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
