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MedKoo Cat#: 412542 | Name: Ceftazidime sodium

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Ceftazidime is a third-generation cephalosporin antibiotic with potent activity against a broad range of Gram-negative bacteria, including Pseudomonas aeruginosa. Its antibacterial action is mediated by inhibition of bacterial cell wall synthesis via high affinity binding to penicillin-binding proteins (PBPs). Ceftazidime exhibits minimum inhibitory concentrations (MICs) typically ranging from 0.25 to 8 µg/mL for susceptible strains of Escherichia coli, Klebsiella pneumoniae, and P. aeruginosa, with an MIC90 of ~4 µg/mL against many Enterobacteriaceae. It is ineffective against most Gram-positive bacteria and anaerobes. Resistance is primarily mediated by extended-spectrum β-lactamases (ESBLs) and AmpC β-lactamase overexpression. Ceftazidime has been widely used for serious infections such as nosocomial pneumonia, bacteremia, and urinary tract infections, often in hospitalized settings.

Chemical Structure

Ceftazidime sodium
Ceftazidime sodium
CAS#73547-61-2 (sodium)

Theoretical Analysis

MedKoo Cat#: 412542

Name: Ceftazidime sodium

CAS#: 73547-61-2 (sodium)

Chemical Formula: C22H21N6NaO7S2

Exact Mass: 0.0000

Molecular Weight: 568.55

Elemental Analysis: C, 46.48; H, 3.72; N, 14.78; Na, 4.04; O, 19.70; S, 11.28

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
72558-82-8 (free) 73547-70-3 (2HCl) 73547-61-2 (sodium) 78439-06-2 (free and hydrate)
Synonym
Ceftazidime sodium; Fortaz; GR 20263 monosodium salt; UNII-CMC30V039K
IUPAC/Chemical Name
sodium (6R,7R)-7-((Z)-2-(2-aminothiazol-4-yl)-2-(((2-carboxylatopropan-2-yl)oxy)imino)acetamido)-8-oxo-3-(pyridin-1-ium-1-ylmethyl)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
InChi Key
JEEWDSDYUSEQML-ROMZVAKDSA-M
InChi Code
InChI=1S/C22H22N6O7S2.Na/c1-22(2,20(33)34)35-26-13(12-10-37-21(23)24-12)16(29)25-14-17(30)28-15(19(31)32)11(9-36-18(14)28)8-27-6-4-3-5-7-27;/h3-7,10,14,18H,8-9H2,1-2H3,(H4-,23,24,25,29,31,32,33,34);/q;+1/p-1/b26-13-;/t14-,18-;/m1./s1
SMILES Code
O=C1[C@@H](NC(/C(C2=CSC(N)=N2)=N\OC(C)(C([O-])=O)C)=O)[C@@]3([H])SCC(C[N+]4=CC=CC=C4)=C(C([O-])=O)N13.[Na+]
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 568.55 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Jones TE, Selby PR, Mellor CS, Cheam DB. Ceftazidime stability and pyridine toxicity during continuous i.v. infusion. Am J Health Syst Pharm. 2019 Feb 1;76(4):200-205. doi: 10.1093/ajhp/zxy035. PMID: 30715181. 2: Hussar DA, Friedman J. Ceftazidime pentahydrate/avibactam sodium, Isavuconazonium sulfate, and Daclatasvir dihydrochloride. J Am Pharm Assoc (2003). 2016 Jan;56(1):100-3. doi: 10.1016/j.japh.2015.12.003. PMID: 26802929. 3: Manduru M, Fariello A, White RL, Fox JL, Bosso JA. Stability of ceftazidime sodium and teicoplanin sodium in a peritoneal dialysis solution. Am J Health Syst Pharm. 1996 Nov 15;53(22):2731-4. doi: 10.1093/ajhp/53.22.2731. PMID: 8931816. 4: Hauser G, Blažević I, Salkić N, Poropat G, Giljača V, Bulić Z, Štimac D. Diclofenac sodium versus ceftazidime for preventing pancreatitis after endoscopic retrograde cholangiopancreatography: a prospective, randomized, controlled trial. Surg Endosc. 2017 Feb;31(2):602-610. doi: 10.1007/s00464-016-5004-9. Epub 2016 Jun 17. Erratum in: Surg Endosc. 2017 Feb;31(2):611. PMID: 27317032. 5: Kampf G. Biocidal Agents Used for Disinfection Can Enhance Antibiotic Resistance in Gram-Negative Species. Antibiotics (Basel). 2018 Dec 14;7(4):110. doi: 10.3390/antibiotics7040110. PMID: 30558235; PMCID: PMC6316403. 6: Stiles ML, Tu YH, Allen LV Jr. Stability of cefazolin sodium, cefoxitin sodium, ceftazidime, and penicillin G sodium in portable pump reservoirs. Am J Hosp Pharm. 1989 Jul;46(7):1408-12. PMID: 2667354. 7: Hauser G, Blažević I, Salkić N, Poropat G, Giljača V, Bulić Z, Štimac D. Erratum to: Diclofenac sodium versus ceftazidime for preventing pancreatitis after endoscopic retrograde cholangiopancreatography: a prospective, randomized, controlled trial. Surg Endosc. 2017 Feb;31(2):611. doi: 10.1007/s00464-016-5305-z. Erratum for: Surg Endosc. 2017 Feb;31(2):602-610. PMID: 27815741. 8: Xu M, Warren FW, Bartlett MG. Stability of low-concentration ceftazidime in 0.9% sodium chloride injection and balanced salt solutions in plastic syringes under various storage conditions. Int J Pharm Compd. 2009 Mar-Apr;13(2):166-9. PMID: 23970010. 9: Verhagen C, De Pauw BE, Williams KJ, Du Bois W. Ceftazidime sodium carbonate versus ceftazidime arginine as empirical monotherapy in febrile neutropenic patients. Eur J Clin Microbiol Infect Dis. 1988 Apr;7(2):178-82. doi: 10.1007/BF01963075. PMID: 3134208. 10: Stiles ML, Allen LV Jr, Fox JL. Stability of ceftazidime (with arginine) and of cefuroxime sodium in infusion-pump reservoirs. Am J Hosp Pharm. 1992 Nov;49(11):2761-4. PMID: 1471642.