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MedKoo Cat#: 575090 | Name: Mafosfamide-lysine

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Mafosfamide-lysine is a salt of cyclophosphamide.

Chemical Structure

Mafosfamide-lysine
Mafosfamide-lysine
CAS#98845-64-8 (lysine)

Theoretical Analysis

MedKoo Cat#: 575090

Name: Mafosfamide-lysine

CAS#: 98845-64-8 (lysine)

Chemical Formula: C15H33Cl2N4O7PS2

Exact Mass: 546.0905

Molecular Weight: 547.44

Elemental Analysis: C, 32.91; H, 6.08; Cl, 12.95; N, 10.23; O, 20.46; P, 5.66; S, 11.71

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
Bulk Inquiry
Related CAS #
88859-04-5 (free acid) 84211-05-2 (sodium) 84210-80-0 (CHA salt) 98845-64-8 (lysine)
Synonym
Asta 7654; Asta Z 7654; Mafosfamide-lysine
IUPAC/Chemical Name
L-lysine compound with 2-(((2S,4S)-2-(bis(2-chloroethyl)amino)-2-oxido-1,3,2-oxazaphosphinan-4-yl)thio)ethane-1-sulfonic acid (1:1)
InChi Key
DYLRFXGKCIFZAH-NNDOHRJVSA-N
InChi Code
InChI=1S/C9H19Cl2N2O5PS2.C6H14N2O2/c10-2-4-13(5-3-11)19(14)12-9(1-6-18-19)20-7-8-21(15,16)17;7-4-2-1-3-5(8)6(9)10/h9H,1-8H2,(H,12,14)(H,15,16,17);5H,1-4,7-8H2,(H,9,10)/t9-,19-;5-/m00/s1
SMILES Code
NCCCC[C@H](N)C(=O)O.OS(=O)(=O)CCS[C@H]1CCO[P@@](=O)(N1)N(CCCl)CCCl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 547.44 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1. Mazur L, Opydo-Chanek M, Stojak M, Wojcieszek K. Mafosfamide as a new anticancer agent: preclinical investigations and clinical trials. Anticancer Res. 2012 Jul;32(7):2783-9. PMID: 22753738. 2. Jacob E, Scorsone K, Blaney SM, D'Argenio DZ, Berg SL. Synergy of karenitecin and mafosfamide in pediatric leukemia, medulloblastoma, and neuroblastoma cell lines. Pediatr Blood Cancer. 2008 Apr;50(4):757-60. doi: 10.1002/pbc.21330. PMID: 17849472; PMCID: PMC2975705.