Mafosfamide is a synthetic oxazaphosphorine derivative with antineoplastic properties. Mafosfamide alkylates DNA, forming DNA cross-links and inhibiting DNA synthesis. Although closely related to cyclophosphamide, mafosfamide, unlike cyclophosphamide, does not require hepatic activation to generate its active metabolite 4-hydroxy-cyclophosphamide; accordingly, mafosfamide is potentially useful in the intrathecal treatment of neoplastic meningitis.
MedKoo Cat#: 574528
Name: Mafosfamide sodium
CAS#: 84211-05-2 (sodium)
Chemical Formula: C9H18Cl2N2NaO5PS2
Exact Mass:
Molecular Weight: 423.24
Elemental Analysis: C, 25.54; H, 4.29; Cl, 16.75; N, 6.62; Na, 5.43; O, 18.90; P, 7.32; S, 15.15
The following data is based on the product molecular weight 423.24 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
