ARM-210 hemifumarate | CAS# 1467606-11-6 | Biochemical

MedKoo Cat#: 575021 | Name: ARM-210 hemifumarate (discontinued)

Description:

WARNING: This product is for research use only, not for human or veterinary use.

ARM-210 was discontinued for commercial reasons.

Chemical Structure

ARM-210 hemifumarate (discontinued)

CAS#1467606-11-6 (hemifumarate)

Theoretical Analysis

MedKoo Cat#: 575021

Name: ARM-210 hemifumarate (discontinued)

CAS#: 1467606-11-6 (hemifumarate)

Chemical Formula: C40H42N2O10S2

Exact Mass: 774.2281

Molecular Weight: 774.90

Elemental Analysis: C, 62.00; H, 5.46; N, 3.62; O, 20.65; S, 8.27

Price and Availability

This product was removed for the commercial reasons.

Related CAS #

1467605-57-7 (free base) 1467606-11-6 (hemifumarate)

Synonym

ARM-210 hemifumarate; ARM210; ARM-210; ARM 210; S48168; S 48168; S-48168

IUPAC/Chemical Name

Benzoic acid, 4-((2,3-dihydro-7-methoxy-1,4-benzothiazepin-4(5H)-yl)methyl)-, (2E)-2-butenedioate (2:1)

InChi Key

KPOXJHIAEVDHMU-WXXKFALUSA-N

InChi Code

InChI=1S/2C18H19NO3S.C4H4O4/c2*1-22-16-6-7-17-15(10-16)12-19(8-9-23-17)11-13-2-4-14(5-3-13)18(20)21;5-3(6)1-2-4(7)8/h2*2-7,10H,8-9,11-12H2,1H3,(H,20,21);1-2H,(H,5,6)(H,7,8)/b;;2-1+

SMILES Code

COc1ccc2SCCN(Cc3ccc(cc3)C(=O)O)Cc2c1.COc4ccc5SCCN(Cc6ccc(cc6)C(=O)O)Cc5c4.OC(=O)\C=C\C(=O)O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 774.90 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1. Capogrosso RF, Mantuano P, Uaesoontrachoon K, Cozzoli A, Giustino A, Dow T, Srinivassane S, Filipovic M, Bell C, Vandermeulen J, Massari AM, De Bellis M, Conte E, Pierno S, Camerino GM, Liantonio A, Nagaraju K, De Luca A. Ryanodine channel complex stabilizer compound S48168/ARM210 as a disease modifier in dystrophin-deficient mdx mice: proof-of-concept study and independent validation of efficacy. FASEB J. 2018 Feb;32(2):1025-1043. doi: 10.1096/fj.201700182RRR. Epub 2018 Jan 3. PMID: 29097503; PMCID: PMC5888399.