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MedKoo Cat#: 564313 | Name: MK-8970

Description:

WARNING: This product is for research use only, not for human or veterinary use.

MK-8970 is an acetal carbonate prodrug of raltegravir with enhanced colonic absorption.

Chemical Structure

MK-8970
MK-8970
CAS#NONE

Theoretical Analysis

MedKoo Cat#: 564313

Name: MK-8970

CAS#: NONE

Chemical Formula: C25H29FN6O8

Exact Mass: 560.2031

Molecular Weight: 560.54

Elemental Analysis: C, 53.57; H, 5.21; F, 3.39; N, 14.99; O, 22.83

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
MK8970; MK 8970; MK-8970
IUPAC/Chemical Name
Ethyl (1-((4-((4-fluorobenzyl)carbamoyl)-1-methyl-2-(2-(5-methyl- 1,3,4-oxadiazole-2-carboxamido)propan-2-yl)-6-oxo-1,6-dihydropyrimidin-5-yl)oxy)ethyl) carbonate
InChi Key
RSSRYSPYSWIJRL-UHFFFAOYSA-N
InChi Code
InChI=1S/C25H29FN6O8/c1-7-37-24(36)40-14(3)39-18-17(19(33)27-12-15-8-10-16(26)11-9-15)28-23(32(6)22(18)35)25(4,5)29-20(34)21-31-30-13(2)38-21/h8-11,14H,7,12H2,1-6H3,(H,27,33)(H,29,34)
SMILES Code
O=C(OCC)OC(OC1=C(C(NCC2=CC=C(F)C=C2)=O)N=C(C(C)(NC(C3=NN=C(C)O3)=O)C)N(C)C1=O)C
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 560.54 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Walji AM, Sanchez RI, Clas SD, Nofsinger R, de Lera Ruiz M, Li J, Bennet A, John C, Bennett DJ, Sanders JM, Di Marco CN, Kim SH, Balsells J, Ceglia SS, Dang Q, Manser K, Nissley B, Wai JS, Hafey M, Wang J, Chessen G, Templeton A, Higgins J, Smith R, Wu Y, Grobler J, Coleman PJ. Discovery of MK-8970: an acetal carbonate prodrug of raltegravir with enhanced colonic absorption. ChemMedChem. 2015 Feb;10(2):245-52. doi: 10.1002/cmdc.201402393. Epub 2014 Dec 2. PubMed PMID: 25469982.