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MedKoo Cat#: 574979 | Name: Tretoquinol HCl

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Tretoquinol, also known as AQ-110 and tretoquinol hydrochloride, is a β2-adrenergic receptor agonist used to treat asthma and chronic obstructive pulmonary disease. Although Tretoquinol possesses a catechol group, it was found not to be a substrate for catechol-O-methyl transferase and this is considered to account for its significantly prolonged action.

Chemical Structure

Tretoquinol HCl
Tretoquinol HCl
CAS#18559-59-6 (HCl)

Theoretical Analysis

MedKoo Cat#: 574979

Name: Tretoquinol HCl

CAS#: 18559-59-6 (HCl)

Chemical Formula: C19H24ClNO5

Exact Mass: 381.1343

Molecular Weight: 381.85

Elemental Analysis: C, 59.76; H, 6.34; Cl, 9.28; N, 3.67; O, 20.95

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
72534-66-8 (HCl hydrate) 18559-59-6 (HCl) 30418-38-3 (free base)
Synonym
l-Trimetoquinol; Tretoquinol l-form hydrochloride; Trimetoquinol-hydrochloride; AQ-110; AQ110; AQ 110;
IUPAC/Chemical Name
1-(3,4,5-Trimethoxybenzyl)-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline hydrochloride, L-
InChi Key
UHSXRTHJCJGEKG-UQKRIMTDSA-N
InChi Code
InChI=1S/C19H23NO5.ClH/c1-23-17-7-11(8-18(24-2)19(17)25-3)6-14-13-10-16(22)15(21)9-12(13)4-5-20-14;/h7-10,14,20-22H,4-6H2,1-3H3;1H/t14-;/m0./s1
SMILES Code
Cl.COc1cc(C[C@@H]2NCCc3cc(O)c(O)cc23)cc(OC)c1OC
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 381.85 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Contu VR, Kotake Y, Toyama T, Okuda K, Miyara M, Sakamoto S, Samizo S, Sanoh S, Kumagai Y, Ohta S. Endogenous neurotoxic dopamine derivative covalently binds to Parkinson's disease-associated ubiquitin C-terminal hydrolase L1 and alters its structure and function. J Neurochem. 2014 Sep;130(6):826-38. doi: 10.1111/jnc.12762. Epub 2014 Jun 18. PubMed PMID: 24832624. 2: Whiting DM, Tomycz ND, Bailes J, de Jonge L, Lecoultre V, Wilent B, Alcindor D, Prostko ER, Cheng BC, Angle C, Cantella D, Whiting BB, Mizes JS, Finnis KW, Ravussin E, Oh MY. Lateral hypothalamic area deep brain stimulation for refractory obesity: a pilot study with preliminary data on safety, body weight, and energy metabolism. J Neurosurg. 2013 Jul;119(1):56-63. doi: 10.3171/2013.2.JNS12903. Epub 2013 Apr 5. PubMed PMID: 23560573. 3: Fogelman F, Grundy HF. A comparison of the cardiovascular actions of AQ 110 with those of isoprenaline and salbutamol. Br J Pharmacol. 1970 Feb;38(2):416-32. PubMed PMID: 4392103; PubMed Central PMCID: PMC1702809.