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MedKoo Cat#: 125835 | Name: Tracazolate

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Tracazolate (ICI 136,753), a pyrazolopyridine, is a non-benzodiazepine with anxiolytic-like activity in animal models.

Chemical Structure

Tracazolate
Tracazolate
CAS#41094-88-6 (free base)

Theoretical Analysis

MedKoo Cat#: 125835

Name: Tracazolate

CAS#: 41094-88-6 (free base)

Chemical Formula: C16H24N4O2

Exact Mass: 304.1900

Molecular Weight: 304.39

Elemental Analysis: C, 63.13; H, 7.95; N, 18.41; O, 10.51

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
41094-88-6 (free base) 1135210-68-2 (HCl)
Synonym
Tracazolate; 41094-88-6; ICI 136,753; ICI-136753; ICI-136,753
IUPAC/Chemical Name
ethyl 4-(butylamino)-1-ethyl-6-methyl-1H-pyrazolo[3,4-b]pyridine-5-carboxylate
InChi Key
PCTRYMLLRKWXGF-UHFFFAOYSA-N
InChi Code
InChI=1S/C16H24N4O2/c1-5-8-9-17-14-12-10-18-20(6-2)15(12)19-11(4)13(14)16(21)22-7-3/h10H,5-9H2,1-4H3,(H,17,19)
SMILES Code
CCCCNC1=C(C(=O)OCC)C(C)=NC2=C1C=NN2CC
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 304.39 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1. Thompson SA, Wingrove PB, Connelly L, Whiting PJ, Wafford KA. Tracazolate reveals a novel type of allosteric interaction with recombinant gamma-aminobutyric acid(A) receptors. Mol Pharmacol. 2002 Apr;61(4):861-9. doi: 10.1124/mol.61.4.861. PMID: 11901225. 2. Melgar MD, Zuleski FR, Malbica JO. Metabolism, disposition, and pharmacokinetics of tracazolate in rat and dog. Drug Metab Dispos. 1984 Jul-Aug;12(4):396-402. PMID: 6148204. 3. Patel JB, Malick JB. Pharmacological properties of tracazolate: a new non-benzodiazepine anxiolytic agent. Eur J Pharmacol. 1982 Mar 12;78(3):323-33. doi: 10.1016/0014-2999(82)90034-6. PMID: 6121711. 4. File SE, Pellow S. The anxiolytic but not the sedative properties of tracazolate are reversed by the benzodiazepine receptor antagonist, Ro 15-1788. Neuropsychobiology. 1985;14(4):193-7. doi: 10.1159/000118226. PMID: 2872613.