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MedKoo Cat#: 328209 | Name: Tretoquinol free base

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Tretoquinol, also known as AQ-110 and tretoquinol hydrochloride, is a β2-adrenergic receptor agonist used to treat asthma and chronic obstructive pulmonary disease. Although Tretoquinol possesses a catechol group, it was found not to be a substrate for catechol-O-methyl transferase and this is considered to account for its significantly prolonged action.

Chemical Structure

Tretoquinol free base
Tretoquinol free base
CAS#30418-38-3 (free base)

Theoretical Analysis

MedKoo Cat#: 328209

Name: Tretoquinol free base

CAS#: 30418-38-3 (free base)

Chemical Formula: C19H23NO

Exact Mass: 345.1576

Molecular Weight: 345.40

Elemental Analysis: C, 66.07; H, 6.71; N, 4.06; O, 23.16

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
72534-66-8 (HCl hydrate) 18559-59-6 (HCl) 30418-38-3 (free base)
Synonym
Tretoquinol; tretoquinol; AQ-110; AQ110; AQ 110;
IUPAC/Chemical Name
1-(3,4,5-trimethoxybenzyl)-1,2,3,4-tetrahydroisoquinoline-6,7-diol
InChi Key
RGVPOXRFEPSFGH-UHFFFAOYSA-N
InChi Code
InChI=1S/C19H23NO5/c1-23-17-7-11(8-18(24-2)19(17)25-3)6-14-13-10-16(22)15(21)9-12(13)4-5-20-14/h7-10,14,20-22H,4-6H2,1-3H3
SMILES Code
OC1=CC2=C(C(CC3=CC(OC)=C(OC)C(OC)=C3)NCC2)C=C1O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Related CAS# 30418-38-3 (free base) 18559-59-6 (HCl)

Preparing Stock Solutions

The following data is based on the product molecular weight 345.40 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Contu VR, Kotake Y, Toyama T, Okuda K, Miyara M, Sakamoto S, Samizo S, Sanoh S, Kumagai Y, Ohta S. Endogenous neurotoxic dopamine derivative covalently binds to Parkinson's disease-associated ubiquitin C-terminal hydrolase L1 and alters its structure and function. J Neurochem. 2014 Sep;130(6):826-38. doi: 10.1111/jnc.12762. Epub 2014 Jun 18. PubMed PMID: 24832624. 2: Whiting DM, Tomycz ND, Bailes J, de Jonge L, Lecoultre V, Wilent B, Alcindor D, Prostko ER, Cheng BC, Angle C, Cantella D, Whiting BB, Mizes JS, Finnis KW, Ravussin E, Oh MY. Lateral hypothalamic area deep brain stimulation for refractory obesity: a pilot study with preliminary data on safety, body weight, and energy metabolism. J Neurosurg. 2013 Jul;119(1):56-63. doi: 10.3171/2013.2.JNS12903. Epub 2013 Apr 5. PubMed PMID: 23560573. 3: Fogelman F, Grundy HF. A comparison of the cardiovascular actions of AQ 110 with those of isoprenaline and salbutamol. Br J Pharmacol. 1970 Feb;38(2):416-32. PubMed PMID: 4392103; PubMed Central PMCID: PMC1702809. 4: Kretschmer L, Pratsch AL. Leg swelling after inguinal sentinel lymph node biopsy and primary melanoma excision with a safety margin. J Dtsch Dermatol Ges. 2012 Oct;10(10):733-9. doi: 10.1111/j.1610-0387.2012.07941.x. Epub 2012 Jun 12. PubMed PMID: 22686498. 5: Nelson MR, Lanza LA, Reeder CB, Scott RL, McCullough AE, Chandrasekaran K, Click RL. Histologic remission of cardiac amyloidosis: a case report. Amyloid. 2012 Jun;19(2):106-9. doi: 10.3109/13506129.2012.660892. Epub 2012 Mar 7. PubMed PMID: 22394355. 6: Dainese L, Guarino A, Burba I, Esposito G, Pompilio G, Polvani G, Rossini A. Heart valve engineering: decellularized aortic homograft seeded with human cardiac stromal cells. J Heart Valve Dis. 2012 Jan;21(1):125-34. PubMed PMID: 22474754. 7: Nakajima H, Hoshiyama M, Kiyomoto A. [Studies on tetrahydroisoquinolines. V. Actions of 1-(3, 4, 5-trimethoxybenzyl)-6, 7-dihydroxy-1, 2, 3, 4-tetrahydroisoquinoline HCL (AQ-110) on the guinea-pig papillary muscle]. Nihon Yakurigaku Zasshi. 1969 Mar 20;65(2):34-9. Japanese. PubMed PMID: 5387676. 8: Iwasawa Y, Kiyomoto A. [Studies on tetrahydroisoquinoline compounds. (3). Pharmacodynamics of 1-(3,4,5-trimethoxybenzyl)-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline HC1 (AQ-110)]. Nihon Yakurigaku Zasshi. 1967 Mar 20;63(2):28-42. Japanese. PubMed PMID: 4383100. 9: Comer BT, Young AB, Gal TJ. Impact of endoscopic surgical techniques on efficiency in pituitary surgery. Otolaryngol Head Neck Surg. 2011 Nov;145(5):732-6. doi: 10.1177/0194599811416753. Epub 2011 Jul 22. PubMed PMID: 21785043. 10: Richards D, Davis D, Yan P, Guha S. Unusual case of small cell gastric carcinoma: case report and literature review. Dig Dis Sci. 2011 Apr;56(4):951-7. doi: 10.1007/s10620-010-1404-1. Epub 2010 Sep 18. Review. PubMed PMID: 20848201.