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MedKoo Cat#: 574893 | Name: TC-I 15

Description:

WARNING: This product is for research use only, not for human or veterinary use.

TC-I 15 is an α2β1 integrin inhibitor that reduces collagen IV production in mesangial cells.

Chemical Structure

TC-I 15
TC-I 15
CAS#916734-43-5

Theoretical Analysis

MedKoo Cat#: 574893

Name: TC-I 15

CAS#: 916734-43-5

Chemical Formula: C23H28N4O6S2

Exact Mass: 520.1450

Molecular Weight: 520.62

Elemental Analysis: C, 53.06; H, 5.42; N, 10.76; O, 18.44; S, 12.32

Price and Availability

This product was removed for the commercial reasons.
Related CAS #
No Data
Synonym
TC-I 15
IUPAC/Chemical Name
N-[[(4R)-5,5-Dimethyl-3-(phenylsulfonyl)-4-thiazolidinyl]carbonyl]-3-[[[(phenylmethyl)amino]carbonyl]amino]-L-alanine
InChi Key
XKLHCUGVLCGKKX-RBUKOAKNSA-N
InChi Code
InChI=1S/C23H28N4O6S2/c1-23(2)19(27(15-34-23)35(32,33)17-11-7-4-8-12-17)20(28)26-18(21(29)30)14-25-22(31)24-13-16-9-5-3-6-10-16/h3-12,18-19H,13-15H2,1-2H3,(H,26,28)(H,29,30)(H2,24,25,31)/t18-,19+/m0/s1
SMILES Code
O=C(O)[C@H](CNC(NCC1=CC=CC=C1)=O)NC([C@H]2N(S(=O)(C3=CC=CC=C3)=O)CSC2(C)C)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 520.62 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1. Borza et al (2012) Inhibition of integrin α2β1 ameliorates glomerular injury. J.Am.Soc.Nephrol. 23 1027 PMID: 22440900 2. Miller et al (2009) Small-molecule inhibitors of integrin α2β1 that prevent pathological thrombus formation via an allosteric mechanism. Proc.Natl.Acad.Sci.U.S.A. 106 719 PMID: 19141632