MedKoo Cat#: 525237 | Name: GSK-894490A

Description:

WARNING: This product is for research use only, not for human or veterinary use.

GSK-894490A is a non-peptide ghrelin receptor agonist. GSK-894490A crosses the blood/brain barrier and elicit pro-cognitive effects in recognition and spatial learning and memory tests. It may be of great interest as a potential drug target for therapeutic approaches to treat diseases affecting cognition.

Chemical Structure

GSK-894490A
GSK-894490A
CAS#1012035-06-1 (Salt)

Theoretical Analysis

MedKoo Cat#: 525237

Name: GSK-894490A

CAS#: 1012035-06-1 (Salt)

Chemical Formula: C24H30ClN3O4S

Exact Mass:

Molecular Weight: 492.03

Elemental Analysis: C, 58.59; H, 6.15; Cl, 7.21; N, 8.54; O, 13.01; S, 6.52

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
1012035-06-1 (Salt) 874958-61-9 (Free base)
Synonym
GSK-894490A; GSK 894490A; GSK894490A.
IUPAC/Chemical Name
N-(5-((3R,5S)-3,5-dimethylpiperazin-1-yl)-2-methoxyphenyl)-4-(5-methylfuran-2-yl)benzenesulfonamide hydrochloride
InChi Key
GHMVYFVWXHMBEZ-OKZTUQRJSA-N
InChi Code
InChI=1S/C23H31N3O4S.ClH/c1-6-30-18(4)19-7-10-21(11-8-19)31(27,28)25-22-13-20(9-12-23(22)29-5)26-14-16(2)24-17(3)15-26;/h7-13,16-17,24-25H,4,6,14-15H2,1-3,5H3;1H/t16-,17+;
SMILES Code
O=S(C1=CC=C(C(OCC)=C)C=C1)(NC2=CC(N3C[C@@H](C)N[C@@H](C)C3)=CC=C2OC)=O.[H]Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 492.03 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Ferens DM, Yin L, Bron R, Hunne B, Ohashi-Doi K, Kitchener PD, Sanger GJ, Witherington J, Shimizu Y, Furness JB. Functional and in situ hybridization evidence that preganglionic sympathetic vasoconstrictor neurons express ghrelin receptors. Neuroscience. 2010 Mar 17;166(2):671-9. doi: 10.1016/j.neuroscience.2010.01.001. Epub 2010 Jan 6. PubMed PMID: 20060438. 2: Atcha Z, Chen WS, Ong AB, Wong FK, Neo A, Browne ER, Witherington J, Pemberton DJ. Cognitive enhancing effects of ghrelin receptor agonists. Psychopharmacology (Berl). 2009 Oct;206(3):415-27. doi: 10.1007/s00213-009-1620-6. Epub 2009 Aug 4. PubMed PMID: 19652956.