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MedKoo Cat#: 528513 | Name: NC-1300-B

Description:

WARNING: This product is for research use only, not for human or veterinary use.

NC-1300-B is a proton pump inhibitor potentially for treatment of gastric ulcer. H(+)-K(+)-ATPase inhibition with NC-1300-B causes profound renal vasodilation and inhibition of renin release without affecting regulation of GFR.

Chemical Structure

NC-1300-B
NC-1300-B
CAS#104340-52-5

Theoretical Analysis

MedKoo Cat#: 528513

Name: NC-1300-B

CAS#: 104340-52-5

Chemical Formula: C17H19N3OS

Exact Mass: 313.1249

Molecular Weight: 313.42

Elemental Analysis: C, 65.15; H, 6.11; N, 13.41; O, 5.10; S, 10.23

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
NC-1300-B; NC1300B; NC 1300 B
IUPAC/Chemical Name
N,N-dimethyl-2-(((6-methyl-1H-benzo[d]imidazol-2-yl)sulfinyl)methyl)aniline
InChi Key
NEGXXYIOWVTFAE-UHFFFAOYSA-N
InChi Code
InChI=1S/C17H19N3OS/c1-12-8-9-14-15(10-12)19-17(18-14)22(21)11-13-6-4-5-7-16(13)20(2)3/h4-10H,11H2,1-3H3,(H,18,19)
SMILES Code
O=S(CC1=CC=CC=C1N(C)C)C2=NC3=CC=C(C)C=C3N2
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 313.42 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Lin H, Young DB. Reduction in renin release and renal vascular resistance by H(+)-K(+)-ATPase inhibition. Am J Physiol. 1997 Sep;273(3 Pt 2):F457-62. PubMed PMID: 9321920. 2: Rhoden KJ, Tallini G, Douglas JS. H+-K+ ATPase inhibitors cause relaxation of guinea pig and human airway smooth muscle in vitro. J Pharmacol Exp Ther. 1996 Mar;276(3):897-903. PubMed PMID: 8786567. 3: McCabe RD, Young DB. Evidence of a K(+)-H(+)-ATPase in vascular smooth muscle cells. Am J Physiol. 1992 Jun;262(6 Pt 2):H1955-8. PubMed PMID: 1320341. 4: Okabe S, Akimoto Y, Yamasaki S, Nagai H. Effects of NC-1300-B, a new benzimidazole derivative, on hog gastric H+, K+-ATPase, gastric acid secretion and HCl.ethanol-induced gastric lesions in rats. Dig Dis Sci. 1988 Nov;33(11):1425-34. PubMed PMID: 2846250.