(R)-MG132 | CAS# 1211877-36-9 | Proteasome inhibitor

MedKoo Cat#: 574782 | Name: (R)-MG132

Featured

Description:

WARNING: This product is for research use only, not for human or veterinary use.

(R)-MG132 is a potent, reversible, and cell permeable proteasome inhibitor. (R)-MG132 is an SRS isomer. MG132 is an SSS isomer.

Chemical Structure

(R)-MG132

CAS#1211877-36-9 (SRS-isomer)

Theoretical Analysis

MedKoo Cat#: 574782

Name: (R)-MG132

CAS#: 1211877-36-9 (SRS-isomer)

Chemical Formula: C26H41N3O5

Exact Mass: 475.3046

Molecular Weight: 475.63

Elemental Analysis: C, 65.66; H, 8.69; N, 8.83; O, 16.82

Price and Availability

Size	Price	Availability
1mg	USD 350.00	2 Weeks
5mg	USD 750.00	2 Weeks
10mg	USD 1,250.00	2 Weeks

Bulk Inquiry

Buy Now

Add to Cart

Related CAS #

133407-82-6 (SSS-isomer) 1211877-36-9 (SRS-isomer)

Synonym

(R)-MG132; (R)-MG-132; (R)-MG 132;

IUPAC/Chemical Name

benzyl ((S)-4-methyl-1-(((R)-4-methyl-1-(((S)-4-methyl-1-oxopentan-2-yl)amino)-1-oxopentan-2-yl)amino)-1-oxopentan-2-yl)carbamate

InChi Key

TZYWCYJVHRLUCT-ZRBLBEILSA-N

InChi Code

InChI=1S/C26H41N3O5/c1-17(2)12-21(15-30)27-24(31)22(13-18(3)4)28-25(32)23(14-19(5)6)29-26(33)34-16-20-10-8-7-9-11-20/h7-11,15,17-19,21-23H,12-14,16H2,1-6H3,(H,27,31)(H,28,32)(H,29,33)/t21-,22+,23-/m0/s1

SMILES Code

[C@H](NC([C@@H](NC(OCC1=CC=CC=C1)=O)CC(C)C)=O)(C(N[C@@H](CC(C)C)C=O)=O)CC(C)C

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 475.63 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1. Lee, D.H., and Goldberg, A.L. Proteasome inhibitors: Valuable new tools for cell biologists. Trends in Cell Biology 8, 397-403 (1998). 2. Elliott, P.J., Zollner, T.M., and Boehncke, W.H. Proteasome inhibition: A new anti-inflammatory strategy. Journal of Molecular Medicine 81, 235-245 (2003). 3. Mroczkiewicz, M., Winkler, K., Nowis, D., et al. Studies of the synthesis of all stereoisomers of MG-132 proteasome inhibitors in the tumor targeting approach. Journal of Medicinal Chemistry 53, 1509-1518 (2010). Product Citations Change, Y.-C., Chen, Y.-J., Huang, C.-W., et al. Cyclic stretch facilitates myogenesis in C2C12 myoblasts and rescues thiazolidinedione-inhibited myotube formation. Front. Bioeng. Biotechnol. 4(27), (2016). 5: Jing, H., Shen, G., Wang, G., Zhang, F., Li, Y., Luo, F., ... & Tian, X. F. (2012). MG132 alleviates liver injury induced by intestinal ischemia/reperfusion in rats: involvement of the AhR and NFκB pathways. Journal of Surgical Research, 176(1), 63-73. 6: Yin, H., Jiang, Y., Li, H., Li, J., Gui, Y., & Zheng, X. L. (2011). Proteasomal degradation of myocardin is required for its transcriptional activity in vascular smooth muscle cells. Journal of cellular physiology, 226(7), 1897-1906.