Ibuprofen | CAS#15687-27-1

MedKoo Cat#: 318050 | Name: Ibuprofen

Featured

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Ibuprofen, from isobutylphenylpropanoic acid, is a nonsteroidal anti-inflammatory drug (NSAID) used for treating pain, fever, and inflammation. This includes painful menstrual periods, migraines, and rheumatoid arthritis.

Chemical Structure

Ibuprofen

CAS#15687-27-1 (free acid)

Theoretical Analysis

MedKoo Cat#: 318050

Name: Ibuprofen

CAS#: 15687-27-1 (free acid)

Chemical Formula: C13H18O2

Exact Mass: 206.1307

Molecular Weight: 206.28

Elemental Analysis: C, 75.69; H, 8.80; O, 15.51

Price and Availability

Size	Price	Availability	Quantity
5g	USD 250.00	2 Weeks
25g	USD 450.00	2 Weeks

Bulk Inquiry

Buy Now

Add to Cart

Related CAS #

15687-27-1 (free acid) 61054-06-6 (Aluminum) 57469-82-6 (arginine) 57469-76-8 (lysinate) 57469-77-9 (lysine) 135861-34-6 (meglumine) 79261-49-7 (potassium) 31121-93-4 (sodium) 527688-20-6 (sodium hydrate)

Synonym

Ibuprofen, Advil, Motrin, Nurofen, Brufen

IUPAC/Chemical Name

2-[4-(2-methylpropyl)phenyl]propanoic acid

InChi Key

HEFNNWSXXWATRW-UHFFFAOYSA-N

InChi Code

InChI=1S/C13H18O2/c1-9(2)8-11-4-6-12(7-5-11)10(3)13(14)15/h4-7,9-10H,8H2,1-3H3,(H,14,15)

SMILES Code

CC(C1=CC=C(CC(C)C)C=C1)C(O)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO, not in water

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 206.28 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Moore RA, Derry S, Wiffen PJ, Straube S, Aldington DJ. Overview review: Comparative efficacy of oral ibuprofen and paracetamol (acetaminophen) across acute and chronic pain conditions. Eur J Pain. 2015 Oct;19(9):1213-23. doi: 10.1002/ejp.649. Epub 2014 Dec 22. Review. PubMed PMID: 25530283. 2: Derry S, Wiffen PJ, Moore RA. Single dose oral ibuprofen plus caffeine for acute postoperative pain in adults. Cochrane Database Syst Rev. 2015 Jul 14;7:CD011509. doi: 10.1002/14651858.CD011509.pub2. Review. PubMed PMID: 26171993. 3: Ohlsson A, Walia R, Shah SS. Ibuprofen for the treatment of patent ductus arteriosus in preterm or low birth weight (or both) infants. Cochrane Database Syst Rev. 2015 Feb 18;2:CD003481. doi: 10.1002/14651858.CD003481.pub6. Review. PubMed PMID: 25692606. 4: Koh W, Nguyen KP, Jahr JS. Intravenous non-opioid analgesia for peri- and postoperative pain management: a scientific review of intravenous acetaminophen and ibuprofen. Korean J Anesthesiol. 2015 Feb;68(1):3-12. doi: 10.4097/kjae.2015.68.1.3. Epub 2015 Jan 28. Review. PubMed PMID: 25664148; PubMed Central PMCID: PMC4318862. 5: Kelly LE, Sommer DD, Ramakrishna J, Hoffbauer S, Arbab-Tafti S, Reid D, Maclean J, Koren G. Morphine or Ibuprofen for post-tonsillectomy analgesia: a randomized trial. Pediatrics. 2015 Feb;135(2):307-13. doi: 10.1542/peds.2014-1906. PubMed PMID: 25624387. 6: Derry S, Karlin SM, Moore RA. Single dose oral ibuprofen plus codeine for acute postoperative pain in adults. Cochrane Database Syst Rev. 2015 Feb 5;2:CD010107. doi: 10.1002/14651858.CD010107.pub3. Review. PubMed PMID: 25927097. 7: Wong T, Stang AS, Ganshorn H, Hartling L, Maconochie IK, Thomsen AM, Johnson DW. Combined and alternating paracetamol and ibuprofen therapy for febrile children. Evid Based Child Health. 2014 Sep;9(3):675-729. doi: 10.1002/ebch.1978. Review. PubMed PMID: 25236309. 8: Moore N, Salvo F, Duong M, Blin P, Pariente A. Cardiovascular risks associated with low-dose ibuprofen and diclofenac as used OTC. Expert Opin Drug Saf. 2014 Feb;13(2):167-79. doi: 10.1517/14740338.2014.846324. Epub 2013 Nov 21. Review. PubMed PMID: 24256349. 9: Pacifici GM. Clinical pharmacology of ibuprofen and indomethacin in preterm infants with patent ductus arteriosus. Curr Pediatr Rev. 2014;10(3):216-37. Review. PubMed PMID: 25088343. 10: Moore RA, Derry S, Straube S, Ireson-Paine J, Wiffen PJ. Faster, higher, stronger? Evidence for formulation and efficacy for ibuprofen in acute pain. Pain. 2014 Jan;155(1):14-21. doi: 10.1016/j.pain.2013.08.013. Epub 2013 Aug 19. Review. PubMed PMID: 23969325. 11: Pacifici GM. Differential renal adverse effects of ibuprofen and indomethacin in preterm infants: a review. Clin Pharmacol. 2014 Jul 31;6:111-6. doi: 10.2147/CPAA.S59376. eCollection 2014. Review. PubMed PMID: 25114597; PubMed Central PMCID: PMC4124049. 12: Bailey E, Worthington HV, van Wijk A, Yates JM, Coulthard P, Afzal Z. Ibuprofen and/or paracetamol (acetaminophen) for pain relief after surgical removal of lower wisdom teeth. Cochrane Database Syst Rev. 2013 Dec 12;12:CD004624. doi: 10.1002/14651858.CD004624.pub2. Review. PubMed PMID: 24338830. 13: Patel A, Bell M, O'Connor C, Inchley A, Wibawa J, Lane ME. Delivery of ibuprofen to the skin. Int J Pharm. 2013 Nov 30;457(1):9-13. doi: 10.1016/j.ijpharm.2013.09.019. Epub 2013 Sep 21. Review. PubMed PMID: 24064201. 14: Derry S, Best J, Moore RA. Single dose oral dexibuprofen [S(+)-ibuprofen] for acute postoperative pain in adults. Cochrane Database Syst Rev. 2013 Oct 23;10:CD007550. doi: 10.1002/14651858.CD007550.pub3. Review. PubMed PMID: 24151035. 15: Wong T, Stang AS, Ganshorn H, Hartling L, Maconochie IK, Thomsen AM, Johnson DW. Combined and alternating paracetamol and ibuprofen therapy for febrile children. Cochrane Database Syst Rev. 2013 Oct 30;10:CD009572. doi: 10.1002/14651858.CD009572.pub2. Review. PubMed PMID: 24174375. 16: Deeks ED. Fixed-dose ibuprofen/famotidine: a review of its use to reduce the risk of gastric and duodenal ulcers in patients requiring NSAID therapy. Clin Drug Investig. 2013 Sep;33(9):689-97. doi: 10.1007/s40261-013-0113-x. Review. PubMed PMID: 23881568. 17: Sarzi-Puttini P, Atzeni F, Lanata L, Bagnasco M. Efficacy of ketoprofen vs. ibuprofen and diclofenac: a systematic review of the literature and meta-analysis. Clin Exp Rheumatol. 2013 Sep-Oct;31(5):731-8. Epub 2013 May 17. Review. PubMed PMID: 23711416. 18: Moore PA, Hersh EV. Combining ibuprofen and acetaminophen for acute pain management after third-molar extractions: translating clinical research to dental practice. J Am Dent Assoc. 2013 Aug;144(8):898-908. Review. PubMed PMID: 23904576. 19: Derry CJ, Derry S, Moore RA. Single dose oral ibuprofen plus paracetamol (acetaminophen) for acute postoperative pain. Cochrane Database Syst Rev. 2013 Jun 24;6:CD010210. doi: 10.1002/14651858.CD010210.pub2. Review. PubMed PMID: 23794268. 20: Derry S, Derry CJ, Moore RA. Single dose oral ibuprofen plus oxycodone for acute postoperative pain in adults. Cochrane Database Syst Rev. 2013 Jun 26;6:CD010289. doi: 10.1002/14651858.CD010289.pub2. Review. PubMed PMID: 23801549.