MedKoo Cat#: 578677 | Name: Obtusilactone

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Obtusilactone is a biochemical that has been shown to inhibit VRK1-dependent phosphorylation of BAF1.

Chemical Structure

Obtusilactone
Obtusilactone
CAS#56799-51-0

Theoretical Analysis

MedKoo Cat#: 578677

Name: Obtusilactone

CAS#: 56799-51-0

Chemical Formula: C17H26O3

Exact Mass: 278.1882

Molecular Weight: 278.39

Elemental Analysis: C, 73.35; H, 9.41; O, 17.24

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Obtusilactone
IUPAC/Chemical Name
(3Z,4S)-3-Dodec-11-enylidene-4-hydroxy-5-methylidene-oxolan-2-one
InChi Key
OFUXNQJZVMQBJO-UGEDRFTOSA-N
InChi Code
InChI=1S/C17H26O3/c1-3-4-5-6-7-8-9-10-11-12-13-15-16(18)14(2)20-17(15)19/h3,13,16,18H,1-2,4-12H2/b15-13-/t16-/m1/s1
SMILES Code
O[C@@H]1C(=C)OC(=O)/C/1=C\CCCCCCCCCC=C
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 278.39 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1. Bailly C, Vergoten G. Interaction of obtusilactone B and related butanolide lactones with the barrier-to-autointegration factor 1 (BAF1). A computational study. Curr Res Pharmacol Drug Discov. 2021 Sep 22;2:100059. doi: 10.1016/j.crphar.2021.100059. PMID: 34909681; PMCID: PMC8663951. 2. Kim W, Lyu HN, Kwon HS, Kim YS, Lee KH, Kim DY, Chakraborty G, Choi KY, Yoon HS, Kim KT. Obtusilactone B from Machilus Thunbergii targets barrier-to-autointegration factor to treat cancer. Mol Pharmacol. 2013 Feb;83(2):367-76. doi: 10.1124/mol.112.082578. Epub 2012 Nov 13. PMID: 23150487.