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MedKoo Cat#: 462623 | Name: Polytuftsin

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Polytuftsin is a polymer of THE naturally occurring immunomodulator tuftsin.

Chemical Structure

Polytuftsin
Polytuftsin
CAS#112592-90-2

Theoretical Analysis

MedKoo Cat#: 462623

Name: Polytuftsin

CAS#: 112592-90-2

Chemical Formula: C21H40N8O6

Exact Mass: 500.3071

Molecular Weight: 500.60

Elemental Analysis: C, 50.39; H, 8.05; N, 22.38; O, 19.18

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Tuftsin polymer
IUPAC/Chemical Name
L-threonyl-L-lysyl-L-prolyl-L-arginine
InChi Key
IESDGNYHXIOKRW-YXMSTPNBSA-N
InChi Code
InChI=1S/C21H40N8O6/c1-12(30)16(23)18(32)27-13(6-2-3-9-22)19(33)29-11-5-8-15(29)17(31)28-14(20(34)35)7-4-10-26-21(24)25/h12-16,30H,2-11,22-23H2,1H3,(H,27,32)(H,28,31)(H,34,35)(H4,24,25,26)/t12-,13+,14+,15+,16+/m1/s1
SMILES Code
C[C@H]([C@@H](C(N[C@H](C(N1CCC[C@H]1C(N[C@H](C(O)=O)CCCNC(N)=N)=O)=O)CCCCN)=O)N)O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 500.60 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Gokulan K, Khare S, Rao DN. Increase in the immunogenicity of HIV peptide antigens by chemical linkage to polytuftsin (TKPR40). DNA Cell Biol. 1999 Aug;18(8):623-30. doi: 10.1089/104454999315033. PMID: 10463058. 2: Kumar P, Rao DN. Correlation of T-cell response and lymphokine profile with RESA peptides of Plasmodium falciparum containing a universal T-cell epitope and an immunopotentiator, polytuftsin. Microbiol Immunol. 1999;43(6):561-6. doi: 10.1111/j.1348-0421.1999.tb02442.x. PMID: 10480552. 3: Kumar P, Biswas S, Rao DN. Potentiation of immune response against the RESA peptides of Plasmodium falciparum by incorporating a universal T-cell epitope (CS.T3) and an immunomodulator (polytuftsin), and delivery through liposomes. Microbiol Immunol. 1999;43(6):567-76. doi: 10.1111/j.1348-0421.1999.tb02443.x. PMID: 10480553. 4: Trudelle Y, Brack A, Delmas A, Pedoussaut S, Rivaille P. Synthesis of a new carrier for immunization: polytuftsin. Two examples of its use with peptides selected in the hepatitis B surface antigen. Int J Pept Protein Res. 1987 Jul;30(1):54-60. PMID: 3667078. 5: Gokulan K, Khare S, Rao DN. Construction of chimeric immunogens: Bioactive fragment of human IL-1β or polytuftsin (PT) capable of eliciting immune responses to HIV peptides. Indian J Clin Biochem. 1998 Jul;13(2):111-8. doi: 10.1007/BF02867872. PMID: 23105191; PMCID: PMC3453564. 6: Ivanov BB, Meshcheryakova EA, Andronova TM, Ivanov VT. Dituftsin and polytuftsin induce an anti-peptide IgG response to non-immunogenic peptides in mice. Immunol Invest. 1994 Apr;23(3):201-12. doi: 10.3109/08820139409087800. PMID: 8070848. 7: Dhawan P, Nath I, Rao DN. Polytuftsin: its possible effects and mechanism during macrophage activation. Immunol Lett. 1995 May;46(1-2):177-82. doi: 10.1016/0165-2478(95)00044-6. PMID: 7590916. 8: Pawan K, Ivanov BB, Kabilan L, Rao DN. Construction of a synthetic immunogen: use of the natural immunomodulator polytuftsin in malaria vaccines against RESA antigen of Plasmodium falciparum. Vaccine. 1994 Jul;12(9):819-24. doi: 10.1016/0264-410x(94)90291-7. PMID: 7526572. 9: Surkis R, Rubinraut S, Dagan S, Tzehoval E, Fridkin M, Ben Yoseph R, Catane R. Polytuftsin: a potential precursor for slow release of the phagocytosis stimulating peptide tuftsin. Int J Biochem. 1990;22(2):193-5. doi: 10.1016/0020-711x(90)90183-4. PMID: 2332102. 10: Delmas A, Brack A, Trudelle Y. Studies of the influence of different cross- linking reagents on the immune response against a B-epitope. Bioconjug Chem. 1992 Jan-Feb;3(1):80-4. doi: 10.1021/bc00013a013. PMID: 1377494. 11: Krikorian D, Stavrakoudis A, Biris N, Sakarellos C, Andreu D, de Oliveira E, Mezö G, Majer Z, Hudecz F, Welling-Wester S, Cung MT, Tsikaris V. Influence of sequential oligopeptide carriers on the bioactive structure of conjugated epitopes: comparative study of the conformation of a Herpes simplex virus glycoprotein gD-1 epitope in the free and conjugated form, and protein "built- in" crystal structure. Biopolymers. 2006;84(4):383-99. doi: 10.1002/bip.20486. PMID: 16493659. 12: Shahi S, Kumar P, Kamboj KK, Rao DN. Immune response against the non-repeat region (293-310) of the circumsporozoite protein of Plasmodium vivax. Southeast Asian J Trop Med Public Health. 1997 Dec;28(4):748-56. PMID: 9656398. 13: Ivanov BB, Meshcheriakova EA, Andronova TM, Ivanov VT. Ispol'zovanie sinteticheskikh nositeleĭ i ad''iuvantov dlia povysheniia immunogennosti sinteticheskogo peptida iz CS-belka Plasmodium falciparum [Use of synthetic carriers and adjuvants for increasing the immunogenicity of a synthetic peptide from the CS-protein of Plasmodium falciparum]. Bioorg Khim. 1991 Jun;17(6):732-46. Russian. PMID: 1723268.

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