Memogain, also known as GLN-1062, is an acetylcholinesterase (AChE) inhibitor potentially for the treatment of Alzheimer's disease. Memogain, a pro-drug, liberates galantamine on cleavage by a carboxyesterase in the brain. Memogain has more than 15-fold higher bioavailability in the brain than the same doses of galantamine. In the brain, Memogain is enzymatically cleaved to galantamine, thereby regaining its pharmacological activity as a cholinergic enhancer.
MedKoo Cat#: 527601
Name: Memogain
CAS#: 224169-27-1
Chemical Formula: C24H25NO4
Exact Mass: 391.1784
Molecular Weight: 391.47
Elemental Analysis: C, 73.64; H, 6.44; N, 3.58; O, 16.35
The following data is based on the product molecular weight 391.47 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
