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MedKoo Cat#: 592331 | Name: Polypodine B

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Polypodine B is an ecdysteroid from roots of Leuzea carthamoides.

Chemical Structure

Polypodine B
Polypodine B
CAS#18069-14-2

Theoretical Analysis

MedKoo Cat#: 592331

Name: Polypodine B

CAS#: 18069-14-2

Chemical Formula: C27H44O8

Exact Mass: 496.3036

Molecular Weight: 496.64

Elemental Analysis: C, 65.30; H, 8.93; O, 25.77

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Polypodine B; Ajugasterone A
IUPAC/Chemical Name
Cholest-7-en-6-one, 2,3,5,14,20,22,25-heptahydroxy-, (2beta,3beta,5beta,22R)-
InChi Key
GMFLGNRCCFYOKL-ACCCYTKYSA-N
InChi Code
InChI=1S/C27H44O8/c1-22(2,32)9-8-20(30)25(5,33)19-7-11-26(34)16-12-21(31)27(35)14-18(29)17(28)13-24(27,4)15(16)6-10-23(19,26)3/h12,15,17-20,28-30,32-35H,6-11,13-14H2,1-5H3/t15-,17-,18+,19-,20+,23+,24+,25+,26+,27+/m0/s1
SMILES Code
CC(O)(CC[C@H]([C@](O)([C@H]1CC[C@]2(C3=CC([C@@]4(C[C@H]([C@H](C[C@@]4([C@H]3CC[C@]12C)C)O)O)O)=O)O)C)O)C
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 496.64 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Huang XZ, Cheng CM, Yin Y, Guo JM, Liang H, Dai Y. [Studies on the chemical constituents from the roots of Tinospora sagittata var. yunnanensis (II)]. Zhong Yao Cai. 2010 Oct;33(10):1574-6. Chinese. PubMed PMID: 21355194. 2: Rharrabe K, Sayan F, Lafont R. Dietary effects of four phytoecdysteroids on growth and development of the Indian meal moth, Plodia interpunctella. J Insect Sci. 2010;10:13. doi: 10.1673/031.010.1301. PubMed PMID: 20575744; PubMed Central PMCID: PMC3014659. 3: Crouzet S, Maria A, Dinan L, Lafont R, Girault JP. Ecdysteroids from Cyanotis longifolia Benth. (Commelinaceae). Arch Insect Biochem Physiol. 2009 Dec;72(4):194-209. doi: 10.1002/arch.20329. PubMed PMID: 19760659. 4: Zibareva L, Yeriomina VI, Munkhjargal N, Girault JP, Dinan L, Lafont R. The phytoecdysteroid profiles of 7 species of Silene (Caryophyllaceae). Arch Insect Biochem Physiol. 2009 Dec;72(4):234-48. doi: 10.1002/arch.20331. PubMed PMID: 19750548. 5: Lapenna S, Friz J, Barlow A, Palli SR, Dinan L, Hormann RE. Ecdysteroid ligand-receptor selectivity--exploring trends to design orthogonal gene switches. FEBS J. 2008 Dec;275(23):5785-809. doi: 10.1111/j.1742-4658.2008.06687.x. PubMed PMID: 19021756. 6: Ando H, Fukumura M, Hori Y, Hirai Y, Toriizuka K, Kuchino Y, Ida Y. Two new glucuronide saponins, Achyranthosides G and H, from Achyranthes fauriei root. J Nat Med. 2008 Jan;62(1):57-62. doi: 10.1007/s11418-007-0183-2. Epub 2007 Oct 2. PubMed PMID: 18404343. 7: Toth N, Bathori M. Preparative-scale chromatography of ecdysteroids: a class of biologically active steroids. J Chromatogr Sci. 2008 Feb;46(2):111-6. PubMed PMID: 18366868. 8: Harmatha J, Vokác K, Kmonícková E, Zídek Z. Lack of interference of common phytoecdysteroids with production of nitric oxide by immune-activated mammalian macrophages. Steroids. 2008 Apr;73(4):466-71. doi: 10.1016/j.steroids.2007.12.014. Epub 2008 Feb 19. PubMed PMID: 18243265. 9: Wang YS, Yang JH, Luo SD, Zhang HB, Li L. New cytotoxic steroid from Stachyurus imalaicus var. himalaicus. Molecules. 2007 Mar 17;12(3):536-42. PubMed PMID: 17851408. 10: Li J, Qi H, Qi LW, Yi L, Li P. Simultaneous determination of main phytoecdysones and triterpenoids in radix achyranthis bidentatae by high-performance liquid chromatography with diode array-evaporative light scattering detectors and mass spectrometry. Anal Chim Acta. 2007 Jul 23;596(2):264-72. Epub 2007 May 21. PubMed PMID: 17631105. 11: Li J, Li HJ, Li P, Qi H. Simultaneous qualitation and quantification of four phytoecdysones in Radix Achyranthis Bidentatae by high-performance liquid chromatography with diode array detection. Biomed Chromatogr. 2007 Aug;21(8):823-8. PubMed PMID: 17428012. 12: Santagati NA, Tropea S, Ronsisvalle G. Analysis of ecdysteroids by micellar electrokinetic chromatography with on-line preconcentration. J Chromatogr A. 2005 Jul 15;1081(1):77-86. PubMed PMID: 16013602. 13: Deng YR, Ding L, Wu SX, Wang HQ. [Studies on chemical constituents in herb of Lamium maculatum var. kansuense (II)]. Zhongguo Zhong Yao Za Zhi. 2005 Feb;30(4):272-4. Chinese. PubMed PMID: 15724404. 14: Meng DL, Li X, Wang JH, Li W. A new phytosterone from Achyranthes bidentata B1. J Asian Nat Prod Res. 2005 Apr;7(2):181-4. PubMed PMID: 15621624. 15: Báthori M, Pongrácz Z, Omacht R, Máthé I. Preparative scale purification of shidasterone, 2-deoxy-polypodine b and 9a,20-dihydroxyecdysone from Silene italica ssp. nemoralis. J Chromatogr Sci. 2004 May-Jun;42(5):275-9. PubMed PMID: 15189602. 16: Nakahara Y, Hiraoka T, Iwabuchi K. Growth-promoting effects of ecdysteroids and juvenile hormone on in vitro development of the larval endoparasitoid, Venturia canescens (Hymenoptera: Ichneumonidae). J Insect Physiol. 2000 Apr;46(4):467-476. PubMed PMID: 12770211. 17: Suksamrarn A, Kumpun S, Yingyongnarongkul BE. Ecdysteroids of Vitex scabra stem bark. J Nat Prod. 2002 Nov;65(11):1690-2. PubMed PMID: 12444704. 18: Fábián L, Argay G, Kálmán A, Báthori M. Crystal structures of ecdysteroids: the role of solvent molecules in hydrogen bonding and isostructurality. Acta Crystallogr B. 2002 Aug;58(Pt 4):710-20. Epub 2002 Jul 30. PubMed PMID: 12149562. 19: Kholodova Y. Phytoecdysteroids: biological effects, application in agriculture and complementary medicine (as presented at the 14-th Ecdysone Workshop, July, 2000, Rapperswil, Switzerland). Ukr Biokhim Zh (1999). 2001 May-Jun;73(3):21-9. PubMed PMID: 12035548. 20: Báthori M, Lafont R, Girault JP, Máthé I. [Structural diversity of ecdysteroids of Lychnis flos-cuculi]. Acta Pharm Hung. 2001 Aug;71(2):157-67. Hungarian. PubMed PMID: 11862663.