GX-201 is a potent and selective inhibitor of the voltage-gated sodium channel NaV1.7, exhibiting an IC₅₀ of 3.2 nM and approximately 10-fold selectivity over NaV1.1, NaV1.2, and NaV1.6 channels. It demonstrates a prolonged residency time on NaV1.7, leading to enhanced potency with chronic dosing and sustained efficacy even after plasma clearance. In preclinical models, GX-201 effectively suppresses neuropathic pain, indicating its potential as an analgesic agent.
MedKoo Cat#: 462578
Name: GX 201
CAS#: 1788071-27-1
Chemical Formula: C25H27ClF4N2O4S
Exact Mass: 562.1316
Molecular Weight: 563.00
Elemental Analysis: C, 53.33; H, 4.83; Cl, 6.30; F, 13.50; N, 4.98; O, 11.37; S, 5.69
The following data is based on the product molecular weight 563.00 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
