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MedKoo Cat#: 585430 | Name: Wy 26703

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Wy 26703 is an alpha 2-adrenoreceptor blocking agent that is more selective than yohimbine for postjunctional and central alpha 2-adrenoreceptors as compared with alpha 1-adrenoreceptors.

Chemical Structure

Wy 26703
Wy 26703
CAS#82059-49-2

Theoretical Analysis

MedKoo Cat#: 585430

Name: Wy 26703

CAS#: 82059-49-2

Chemical Formula: C18H29ClN2O2S

Exact Mass: 372.1638

Molecular Weight: 372.95

Elemental Analysis: C, 57.97; H, 7.84; Cl, 9.51; N, 7.51; O, 8.58; S, 8.60

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Wy 26703; Wy26703; Wy-26703
IUPAC/Chemical Name
N-[(11bR)-2,3,4,6,7,11b-hexahydro-1H-benzo[a]quinolizin-2-yl]-N-methylbutane-1-sulfonamide;hydrochloride
InChi Key
NLRPZMYPHMONBW-KWNHMLIUSA-N
InChi Code
InChI=1S/C18H28N2O2S.ClH/c1-3-4-13-23(21,22)19(2)16-10-12-20-11-9-15-7-5-6-8-17(15)18(20)14-16;/h5-8,16,18H,3-4,9-14H2,1-2H3;1H/t16?,18-;/m1./s1
SMILES Code
CCCCS(=O)(N(C1CCN2CCC3=CC=CC=C3[C@@]2([H])C1)C)=O.[H]Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 372.95 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Korstanje C, Doods HN, De Jonge A, Thoolen MJ, Wilffert B, Timmermans PB, Van Zwieten PA. Affinity of WY 26703 for central and peripheral alpha 1- and alpha 2-adrenoreceptors in the rat; comparison with yohimbine. J Auton Pharmacol. 1984 Dec;4(4):287-93. PubMed PMID: 6099362. 2: Paciorek PM, Pierce V, Shepperson NB, Waterfall JF. An investigation into the selectivity of a novel series of benzoquinolizines for alpha 2-adrenoceptors in vivo. Br J Pharmacol. 1984 May;82(1):127-34. PubMed PMID: 6329385; PubMed Central PMCID: PMC1987241. 3: Pettibone DJ, Pfleuger AB, Totaro JA. Comparison of the effects of recently developed alpha 2-adrenergic antagonists with yohimbine and rauwolscine on monoamine synthesis in rat brain. Biochem Pharmacol. 1985 Apr 1;34(7):1093-7. PubMed PMID: 2859020. 4: Lattimer N, McAdams RP, Rhodes KF, Sharma S, Turner SJ, Waterfall JF. Alpha 2-adrenoceptor antagonism and other pharmacological antagonist properties of some substituted benzoquinolizines and yohimbine in vitro. Naunyn Schmiedebergs Arch Pharmacol. 1984 Oct;327(4):312-8. PubMed PMID: 6151116. 5: Angel I, Niddam R, Langer SZ. Involvement of alpha-2 adrenergic receptor subtypes in hyperglycemia. J Pharmacol Exp Ther. 1990 Sep;254(3):877-82. PubMed PMID: 1975624. 6: Bulloch JM, Docherty JR, Flavahan NA, McGrath JC, McKean CE. Difference in the potency of alpha 2-adrenoceptor agonists and antagonists between the pithed rabbit and rat. Br J Pharmacol. 1987 Jul;91(3):457-66. PubMed PMID: 2886172; PubMed Central PMCID: PMC1853567. 7: Pettibone DJ, Clineschmidt BV, Lotti VJ, Martin GE, Huff JR, Randall WC, Vacca J, Baldwin JJ. L-654,284 a new potent and selective alpha 2-adrenoceptor antagonist. Naunyn Schmiedebergs Arch Pharmacol. 1986 Jun;333(2):110-6. PubMed PMID: 2875395. 8: Baxter GS, Murphy OE, Blackburn TP. Further characterization of 5-hydroxytryptamine receptors (putative 5-HT2B) in rat stomach fundus longitudinal muscle. Br J Pharmacol. 1994 May;112(1):323-31. PubMed PMID: 8032658; PubMed Central PMCID: PMC1910288. 9: Daly CJ, McGrath JC, Wilson VG. Pharmacological analysis of postjunctional alpha-adrenoceptors mediating contractions to (-)-noradrenaline in the rabbit isolated lateral saphenous vein can be explained by interacting responses to simultaneous activation of alpha 1- and alpha 2-adrenoceptors. Br J Pharmacol. 1988 Oct;95(2):485-500. PubMed PMID: 2906557; PubMed Central PMCID: PMC1854170. 10: Lien EL, Morrison A, Kassarich J, Sullivan D. Alpha-2-adrenergic control of prolactin release. Neuroendocrinology. 1986;44(2):184-9. PubMed PMID: 3025757. 11: Redfern WS, MacLean MR, Clague RU, McGrath JC. The role of alpha 2-adrenoceptors in the vasculature of the rat tail. Br J Pharmacol. 1995 Apr;114(8):1724-30. PubMed PMID: 7599941; PubMed Central PMCID: PMC1510371. 12: Dabiré H. Idazoxan: a novel pharmacological tool for the study of alpha 2-adrenoceptors. J Pharmacol. 1986 Apr-Jun;17(2):113-8. Review. PubMed PMID: 2875218. 13: Brown CM, MacKinnon AC, McGrath JC, Spedding M, Kilpatrick AT. Alpha 2-adrenoceptor subtypes and imidazoline-like binding sites in the rat brain. Br J Pharmacol. 1990 Apr;99(4):803-9. PubMed PMID: 1972896; PubMed Central PMCID: PMC1917565. 14: Rhodes KF, Waterfall JF. The effects of some alpha-adrenoceptor antagonists on the responses of the canine saphenous vein to B-HT 933, UK-14304 and methoxamine. Naunyn Schmiedebergs Arch Pharmacol. 1987 Mar;335(3):261-8. PubMed PMID: 2884574. 15: Daly CJ, McGrath JC, Wilson VG. Evidence that the population of postjunctional-adrenoceptors mediating contraction of smooth muscle in the rabbit isolated ear vein is predominantly alpha 2. Br J Pharmacol. 1988 Aug;94(4):1085-90. PubMed PMID: 2905182; PubMed Central PMCID: PMC1854110. 16: Doxey JC, Gadie B, Lane AC, Tulloch IF. Evidence for pharmacological similarity between alpha 2-adrenoceptors in the vas deferens and central nervous system of the rat. Br J Pharmacol. 1983 Sep;80(1):155-61. PubMed PMID: 6140052; PubMed Central PMCID: PMC2044981. 17: Gadie B, Lane AC, McCarthy PS, Tulloch IF, Walter DS. 2-Alkyl analogue of idazoxan (RX 781094) with enhanced antagonist potency and selectivity at central alpha 2-adrenoceptors in the rat. Br J Pharmacol. 1984 Nov;83(3):707-12. PubMed PMID: 6150739; PubMed Central PMCID: PMC1987074. 18: Brown CM, MacKinnon AC, McGrath JC, Spedding M, Kilpatrick AT. Heterogeneity of alpha 2-adrenoceptors in rat cortex but not human platelets can be defined by 8-OH-DPAT, RU 24969 and methysergide. Br J Pharmacol. 1990 Mar;99(3):481-6. PubMed PMID: 1970497; PubMed Central PMCID: PMC1917355. 19: Yarbrough GG, Robinson EL, Antolik EK. Antagonism of xylazine plus chloral hydrate loss of the righting reflex in mice. A simple in vivo procedure for the evaluation of selective alpha 2-adrenoceptor antagonists. J Pharmacol Methods. 1984 Jun;11(3):187-93. PubMed PMID: 6145817. 20: MacKinnon AC, Kilpatrick AT, Kenny BA, Spedding M, Brown CM. [3H]-RS-15385-197, a selective and high affinity radioligand for alpha 2-adrenoceptors: implications for receptor classification. Br J Pharmacol. 1992 Aug;106(4):1011-8. PubMed PMID: 1327384; PubMed Central PMCID: PMC1907641.

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