MedKoo Cat#: 562533 | Name: BX430
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

BX430 is a selective allosteric antagonist of human P2X4 receptor channels.

Chemical Structure

BX430
BX430
CAS#688309-70-8

Theoretical Analysis

MedKoo Cat#: 562533

Name: BX430

CAS#: 688309-70-8

Chemical Formula: C15H15Br2N3O

Exact Mass: 410.9582

Molecular Weight: 413.11

Elemental Analysis: C, 43.61; H, 3.66; Br, 38.68; N, 10.17; O, 3.87

Price and Availability

Size Price Availability Quantity
10mg USD 250.00 2 Weeks
25mg USD 500.00 2 Weeks
50mg USD 850.00 2 Weeks
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Related CAS #
No Data
Synonym
BX430; BX-430; BX 430; Blocker of P2X4 Compound 3.0
IUPAC/Chemical Name
N-[2,6-Dibromo-4-(1-methylethyl)phenyl]-N'-3-pyridinyl-urea
InChi Key
JFNKIJKRXKPQCC-UHFFFAOYSA-N
InChi Code
InChI=1S/C15H15Br2N3O/c1-9(2)10-6-12(16)14(13(17)7-10)20-15(21)19-11-4-3-5-18-8-11/h3-9H,1-2H3,(H2,19,20,21)
SMILES Code
O=C(NC1=CC=CN=C1)NC2=C(Br)C=C(C(C)C)C=C2Br
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 413.11 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Layhadi JA, Turner J, Crossman D, Fountain SJ. ATP Evokes Ca(2+) Responses and CXCL5 Secretion via P2X(4) Receptor Activation in Human Monocyte-Derived Macrophages. J Immunol. 2018 Feb 1;200(3):1159-1168. doi: 10.4049/jimmunol.1700965. Epub 2017 Dec 18. PubMed PMID: 29255078; PubMed Central PMCID: PMC5784824. 2: Stokes L, Layhadi JA, Bibic L, Dhuna K, Fountain SJ. P2X4 Receptor Function in the Nervous System and Current Breakthroughs in Pharmacology. Front Pharmacol. 2017 May 23;8:291. doi: 10.3389/fphar.2017.00291. eCollection 2017. Review. PubMed PMID: 28588493; PubMed Central PMCID: PMC5441391. 3: Ase AR, Honson NS, Zaghdane H, Pfeifer TA, Séguéla P. Identification and characterization of a selective allosteric antagonist of human P2X4 receptor channels. Mol Pharmacol. 2015 Apr;87(4):606-16. doi: 10.1124/mol.114.096222. Epub 2015 Jan 16. PubMed PMID: 25597706.