MedKoo Cat#: 574606 | Name: BYK-49187

Description:

WARNING: This product is for research use only, not for human or veterinary use.

BYK-49187 is a PARP-1 and PARP-2 inhibitor that has been shown to reduce myocardial infarct size in vivo.

Chemical Structure

BYK-49187
BYK-49187
CAS# 163120-31-8

Theoretical Analysis

MedKoo Cat#: 574606

Name: BYK-49187

CAS#: 163120-31-8

Chemical Formula: C19H21N5O

Exact Mass: 335.1746

Molecular Weight: 335.41

Elemental Analysis: C, 68.04; H, 6.31; N, 20.88; O, 4.77

Price and Availability

Size Price Availability Quantity
Bulk Inquiry
Buy Now
Add to Cart
Related CAS #
No Data
Synonym
BYK 49187; BYK-49187; BYK49187
IUPAC/Chemical Name
2-(4-(4-methyl-1H-imidazol-5-yl)piperidin-1-yl)-4,5-dihydro-6H-imidazo[4,5,1-ij]quinolin-6-one
InChi Key
YKJJROIKVYSPDH-UHFFFAOYSA-N
InChi Code
InChI=1S/C19H21N5O/c1-12-17(21-11-20-12)13-5-8-23(9-6-13)19-22-15-4-2-3-14-16(25)7-10-24(19)18(14)15/h2-4,11,13H,5-10H2,1H3,(H,20,21)
SMILES Code
O=C1CCN(C(N2CCC(C3=C(C)N=CN3)CC2)=N4)C5=C4C=CC=C15
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 335.41 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1. Eltze et al (2008) Imidazoquinolinone, imidazopyridine, and isoquinolindione derivatives as novel and potent inhibitors of the poly(ADP-ribose) polymerase (PARP): a comparison with standard PARP inhibitors. Mol.Pharmacol. 74 1587 PMID: 18809672 2. Sunderland et al (2011) 5-Benzamidoisoquinolin-1-ones and 5-(omega-carboxyalkyl)isoquinolin-1-ones as isoform-selective inhibitors of poly(ADP-ribose) polymerase 2 (PARP-2). J.Med.Chem. 54 2049 PMID: 21417348