GX-395 | CAS#1235403-87-8 | Nav1.7 inhibitor

MedKoo Cat#: 527686 | Name: GX-395

Description:

WARNING: This product is for research use only, not for human or veterinary use.

GX-395 is a novel inhibitor of Nav1.7.

Chemical Structure

GX-395

CAS#1235403-87-8

Theoretical Analysis

MedKoo Cat#: 527686

Name: GX-395

CAS#: 1235403-87-8

Chemical Formula: C21H17ClF2N6O3S2

Exact Mass: 538.0460

Molecular Weight: 538.97

Elemental Analysis: C, 46.80; H, 3.18; Cl, 6.58; F, 7.05; N, 15.59; O, 8.91; S, 11.90

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

GX395; GX 395; GX-395

IUPAC/Chemical Name

4-{4-Chloro-2-[2-(1-methyl-azetidin-3-yl)-2H-pyrazol-3-yl]-phenoxy}-2,5-difluoro-N-[1,2,4]thiadiazol-5-yl-benzenesulfonamide

InChi Key

QESPTBXFDDSHIF-UHFFFAOYSA-N

InChi Code

InChI=1S/C21H17ClF2N6O3S2/c1-29-9-13(10-29)30-17(4-5-26-30)14-6-12(22)2-3-18(14)33-19-7-16(24)20(8-15(19)23)35(31,32)28-21-25-11-27-34-21/h2-8,11,13H,9-10H2,1H3,(H,25,27,28)

SMILES Code

O=S(C1=CC(F)=C(OC2=CC=C(Cl)C=C2C3=CC=NN3C4CN(C)C4)C=C1F)(NC5=NC=NS5)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 538.97 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Lo HC, Yang JG, Liu BC, Chen YW, Huang YL, Poon SL, Liu MY, Huang BM. The effects of Tremella aurantia on testosterone and corticosterone productions in normal and diabetic rats. Arch Androl. 2004 Nov-Dec;50(6):395-404. PubMed PMID: 15669604. 2: De Luca G, Asso M, Belaich JP, Dermoun Z. Purification and characterization of the HndA subunit of NADP-reducing hydrogenase from Desulfovibrio fructosovorans overproduced in Escherichia coli. Biochemistry. 1998 Feb 24;37(8):2660-5. PubMed PMID: 9485416.