BX 048 | CAS#937395-09-0

MedKoo Cat#: 531651 | Name: BX-048

Description:

WARNING: This product is for research use only, not for human or veterinary use.

BX 048 is an active metabolite of BX 667 which is a novel P2Y12 adenosine diphosphate receptor antagonist for inhibition of platelet aggregation.

Chemical Structure

BX-048

CAS#937395-09-0

Theoretical Analysis

MedKoo Cat#: 531651

Name: BX-048

CAS#: 937395-09-0

Chemical Formula: C27H34N4O9

Exact Mass: 558.2326

Molecular Weight: 558.59

Elemental Analysis: C, 58.06; H, 6.14; N, 10.03; O, 25.78

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

BX 048; BX-048; BX048.

IUPAC/Chemical Name

5-(4-ethoxycarbonylpiperazin-1-yl)-4-[[4-(1-hydroxy-2-methyl-1-oxopropan-2-yl)oxy-7-methylquinoline-2-carbonyl]amino]-5-oxopentanoic acid

InChi Key

MCBLPJPMVOVJCO-UHFFFAOYSA-N

InChi Code

InChI=1S/C27H34N4O9/c1-5-39-26(38)31-12-10-30(11-13-31)24(35)18(8-9-22(32)33)29-23(34)20-15-21(40-27(3,4)25(36)37)17-7-6-16(2)14-19(17)28-20/h6-7,14-15,18H,5,8-13H2,1-4H3,(H,29,34)(H,32,33)(H,36,37)

SMILES Code

O=C(O)CCC(NC(C1=NC2=CC(C)=CC=C2C(OC(C)(C)C(O)=O)=C1)=O)C(N3CCN(C(OCC)=O)CC3)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 558.59 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Post JM, Alexander S, Wang YX, Vincelette J, Vergona R, Kent L, Bryant J, Sullivan ME, Dole WP, Morser J, Subramanyam B. Novel P2Y12 adenosine diphosphate receptor antagonists for inhibition of platelet aggregation (II): pharmacodynamic and pharmacokinetic characterization. Thromb Res. 2008;122(4):533-40. doi: 10.1016/j.thromres.2008.04.009. PubMed PMID: 18539312. 2: Bryant J, Post JM, Alexander S, Wang YX, Kent L, Schirm S, Tseng JL, Subramanyam B, Buckman B, Islam I, Yuan S, Sullivan ME, Snider M, Morser J. Novel P2Y12 adenosine diphosphate receptor antagonists for inhibition of platelet aggregation (I): in vitro effects on platelets. Thromb Res. 2008;122(4):523-32. doi: 10.1016/j.thromres.2008.03.026. PubMed PMID: 18495218. 3: Wang YX, Vincelette J, da Cunha V, Martin-McNulty B, Mallari C, Fitch RM, Alexander S, Islam I, Buckman BO, Yuan S, Post JM, Subramanyam B, Vergona R, Sullivan ME, Dole WP, Morser J, Bryant J. A novel P2Y(12) adenosine diphosphate receptor antagonist that inhibits platelet aggregation and thrombus formation in rat and dog models. Thromb Haemost. 2007 May;97(5):847-55. PubMed PMID: 17479197.