ICI-204448 HCl | CAS#121264-04-8 | KOR Receptor Agonist

MedKoo Cat#: 534907 | Name: ICI-204448 HCl

Description:

WARNING: This product is for research use only, not for human or veterinary use.

ICI-204448 is a potent and peripherally selective κ-opioid agonist, with possible uses in the treatment of heart attack as well as anti-itching effects. It is used in research to distinguish centrally from peripherally mediated kappa opioid receptor effects.

Chemical Structure

ICI-204448 HCl

CAS#121264-04-8 (HCl)

Theoretical Analysis

MedKoo Cat#: 534907

Name: ICI-204448 HCl

CAS#: 121264-04-8 (HCl)

Chemical Formula: C23H27Cl3N2O4

Exact Mass: 0.0000

Molecular Weight: 501.83

Elemental Analysis: C, 55.05; H, 5.42; Cl, 21.19; N, 5.58; O, 12.75

Price and Availability

Size	Price	Availability
50mg	USD 450.00	2 Weeks
100mg	USD 750.00	2 Weeks
200mg	USD 1,250.00	2 Weeks
500mg	USD 2,850.00	2 Weeks
1g	USD 4,250.00	2 Weeks
2g	USD 6,450.00	2 Weeks

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Related CAS #

125190-72-9 (free base) 121264-04-8 (HCl)

Synonym

ICI-204448 HCl; ICI-204448 hydrochloride; ICI-204448; ICI 204448; ICI 204448;

IUPAC/Chemical Name

Acetic acid, (3-(1-(((3,4-dichlorophenyl)acetyl)methylamino)-2-(1-pyrrolidinyl)ethyl)phenoxy)-, monohydrochloride, (+-)-

InChi Key

FNDGLVOYAQNQPE-UHFFFAOYSA-N

InChi Code

InChI=1S/C23H26Cl2N2O4.ClH/c1-26(22(28)12-16-7-8-19(24)20(25)11-16)21(14-27-9-2-3-10-27)17-5-4-6-18(13-17)31-15-23(29)30;/h4-8,11,13,21H,2-3,9-10,12,14-15H2,1H3,(H,29,30);1H

SMILES Code

O=C(O)COC1=CC=CC(C(N(C(CC2=CC=C(Cl)C(Cl)=C2)=O)C)CN3CCCC3)=C1.[H]Cl

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 501.83 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

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Effects of peripheral μ, δ, and Κ-opioid receptor agonists on the levels of anxiety and motor activity of rats. Bull Exp Biol Med. 2012 Sep;153(5):720-1. doi: 10.1007/s10517-012-1809-2. PMID: 23113268. 8: Negus SS, O'Connell R, Morrissey E, Cheng K, Rice KC. Effects of peripherally restricted κ opioid receptor agonists on pain-related stimulation and depression of behavior in rats. J Pharmacol Exp Ther. 2012 Mar;340(3):501-9. doi: 10.1124/jpet.111.186783. Epub 2011 Nov 29. PMID: 22128346; PMCID: PMC3286312. 9: Funez MI, Ferrari LF, Duarte DB, Sachs D, Cunha FQ, Lorenzetti BB, Parada CA, Ferreira SH. Teleantagonism: A pharmacodynamic property of the primary nociceptive neuron. Proc Natl Acad Sci U S A. 2008 Dec 9;105(49):19038-43. doi: 10.1073/pnas.0807922105. Epub 2008 Sep 17. PMID: 18799742; PMCID: PMC2614711. 10: Caram-Salas NL, Reyes-García G, Bartoszyk GD, Araiza-Saldaña CI, Ambriz- Tututi M, Rocha-González HI, Arreola-Espino R, Cruz SL, Granados-Soto V. Subcutaneous, intrathecal and periaqueductal grey administration of asimadoline and ICI-204448 reduces tactile allodynia in the rat. Eur J Pharmacol. 2007 Nov 14;573(1-3):75-83. doi: 10.1016/j.ejphar.2007.06.034. Epub 2007 Jun 29. PMID: 17643411. 11: Werkheiser JL, Rawls SM, Cowan A. Mu and kappa opioid receptor agonists antagonize icilin-induced wet-dog shaking in rats. Eur J Pharmacol. 2006 Oct 10;547(1-3):101-5. doi: 10.1016/j.ejphar.2006.07.026. Epub 2006 Jul 25. PMID: 16945367. 12: Rawls SM, Ding Z, Gray AM, Cowan A. Peripheral kappa-opioid agonist, ICI 204448, evokes hypothermia in cold-exposed rats. Pharmacology. 2005 May;74(2):79-83. doi: 10.1159/000083704. Epub 2005 Jan 12. PMID: 15687734. 13: Kumar V, Guo D, Cassel JA, Daubert JD, Dehaven RN, Dehaven-Hudkins DL, Gauntner EK, Gottshall SL, Greiner SL, Koblish M, Little PJ, Mansson E, Maycock AL. Synthesis and evaluation of novel peripherally restricted kappa-opioid receptor agonists. 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