MedKoo Cat#: 406977 | Name: WHI-P258
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

WHI-P258 is a Janus kinase 3 inhibitor. WHI-P131 may provide the basis for the design of new treatment strategies against acute lymphoblastic leukemia, the most common form of childhood cancer.

Chemical Structure

WHI-P258
WHI-P258
CAS#21561-09-1

Theoretical Analysis

MedKoo Cat#: 406977

Name: WHI-P258

CAS#: 21561-09-1

Chemical Formula: C16H15N3O2

Exact Mass: 281.1164

Molecular Weight: 281.32

Elemental Analysis: C, 68.31; H, 5.37; N, 14.94; O, 11.37

Price and Availability

Size Price Availability Quantity
25mg USD 250.00
50mg USD 450.00
100mg USD 650.00
200mg USD 950.00
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Related CAS #
No Data
Synonym
WHI-P258; WHI-P 258; WHI-P-258; WHIP 258
IUPAC/Chemical Name
6,7-Dimethoxy-N-phenylquinazolin-4-amine
InChi Key
MJKCGAHOCZLYDG-UHFFFAOYSA-N
InChi Code
InChI=1S/C16H15N3O2/c1-20-14-8-12-13(9-15(14)21-2)17-10-18-16(12)19-11-6-4-3-5-7-11/h3-10H,1-2H3,(H,17,18,19)
SMILES Code
COC1=CC2=NC=NC(NC3=CC=CC=C3)=C2C=C1OC
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 281.32 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Sudbeck EA, Liu XP, Narla RK, Mahajan S, Ghosh S, Mao C, Uckun FM. Structure-based design of specific inhibitors of Janus kinase 3 as apoptosis-inducing antileukemic agents. Clin Cancer Res. 1999 Jun;5(6):1569-82. PubMed PMID: 10389946.