JTE-051 is a potent inhibitor of interleukin-2-inducible T cell kinase (ITK), a key enzyme involved in T cell receptor signaling. It inhibits ITK enzymatic activity with an IC₅₀ of approximately 2.2 nM. In cellular assays, JTE-051 suppresses T cell activation and cytokine production, notably reducing IL-2 and IFN-γ secretion in stimulated human peripheral blood T cells. In vivo, JTE-051 demonstrates strong anti-inflammatory effects in several animal models. For instance, in a rat collagen-induced arthritis (CIA) model, oral administration of 10 mg/kg/day significantly suppressed paw swelling and joint histopathology scores. These results support JTE-051’s therapeutic potential in T cell–mediated autoimmune disorders such as rheumatoid arthritis and psoriasis.
MedKoo Cat#: 466148
Name: JTE-051
CAS#: 1309784-09-5
Chemical Formula: C25H33N5O2
Exact Mass: 435.2634
Molecular Weight: 435.57
Elemental Analysis: C, 68.94; H, 7.64; N, 16.08; O, 7.35
The following data is based on the product molecular weight 435.57 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
