IACS-6274 free base| CAS#1853164-83-6 | glutaminase inhibitor

MedKoo Cat#: 207126 | Name: IACS-6274 free base

Description:

WARNING: This product is for research use only, not for human or veterinary use.

IACS-6274, also known as IPN60090, is a potent, selective and orally active glutaminase inhibitor with potential antineoplastic and immunostimulating activities. IPN60090 selectively targets, binds to and inhibits human glutaminase, an enzyme that is essential for the conversion of the amino acid glutamine into glutamate.

Chemical Structure

IACS-6274 free base

CAS#1853164-83-6 (free base)

Theoretical Analysis

MedKoo Cat#: 207126

Name: IACS-6274 free base

CAS#: 1853164-83-6 (free base)

Chemical Formula: C24H27F3N8O3

Exact Mass: 532.2158

Molecular Weight: 532.53

Elemental Analysis: C, 54.13; H, 5.11; F, 10.70; N, 21.04; O, 9.01

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

1853164-83-6 (free base) 2102101-72-2 (HCl) 2102101-77-7 (sulfate) 2102101-78-8 (mesylate) 2102101-80-2 (tosylate)

Synonym

IACS-6274; IACS 6274; IACS6274; IPN60090; IPN-60090; IPN 60090;

IUPAC/Chemical Name

(R)-1-(4-(6-(2-(4-(3,3-difluorocyclobutoxy)-6-methylpyridin-2-yl)acetamido)pyridazin-3-yl)-2-fluorobutyl)-N-methyl-1H-1,2,3-triazole-4-carboxamide

InChi Key

GEHZIZWHNLQFAS-OAHLLOKOSA-N

InChi Code

InChI=1S/C24H27F3N8O3/c1-14-7-18(38-19-10-24(26,27)11-19)8-17(29-14)9-22(36)30-21-6-5-16(31-33-21)4-3-15(25)12-35-13-20(32-34-35)23(37)28-2/h5-8,13,15,19H,3-4,9-12H2,1-2H3,(H,28,37)(H,30,33,36)/t15-/m1/s1

SMILES Code

O=C(NC)C1=CN(C[C@H](F)CCC2=CC=C(NC(CC3=CC(OC4CC(F)(F)C4)=CC(C)=N3)=O)N=N2)N=N1

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Blocking glutamine metabolism inhibits proliferation in rapidly growing tumor cells and leads to an induction of cell death. Unlike normal healthy cells, glutamine-dependent tumors heavily rely on the intracellular conversion of exogenous glutamine into glutamate and glutamate metabolites to provide energy and generate building blocks for the production of macromolecules, which are needed for cellular growth and survival.

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 532.53 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.