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MedKoo Cat#: 462109 | Name: Clobutinol hydrochloride

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Clobutinol is a cough suppressant that is withdrawn from the US and EU markets. Clobutinol may prolong the QT interval. In 2007, Clobutinol was determined to cause cardiac arrhythmia in some patients.

Chemical Structure

Clobutinol hydrochloride
Clobutinol hydrochloride
CAS#1215-83-4 (HCl)

Theoretical Analysis

MedKoo Cat#: 462109

Name: Clobutinol hydrochloride

CAS#: 1215-83-4 (HCl)

Chemical Formula: C14H23Cl2NO

Exact Mass: 291.1157

Molecular Weight: 292.24

Elemental Analysis: C, 57.54; H, 7.93; Cl, 24.26; N, 4.79; O, 5.47

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
14860-49-2 (free base) 1215-83-4 (HCl)
Synonym
Clobutinol hydrochloride
IUPAC/Chemical Name
Benzeneethanol, 4-chloro-alpha-(2-(dimethylamino)-1-methylethyl)-alpha-methyl-, hydrochloride
InChi Key
ZMROYCGIWPNZNJ-UHFFFAOYSA-N
InChi Code
InChI=1S/C14H22ClNO.ClH/c1-11(10-16(3)4)14(2,17)9-12-5-7-13(15)8-6-12;/h5-8,11,17H,9-10H2,1-4H3;1H
SMILES Code
OC(C)(C(C)CN(C)C)CC1=CC=C(Cl)C=C1.[H]Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 292.24 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Boehringer Ingelheim GmbH.Boehringer Ingelheim voluntarily withdraws its clobutinol containing medications. Media Release: 31 Aug 2007. Available from: URL: http://www.boehringer-ingelheim.com 2: Pontiroli, A.E., Daffonchio, L. Efficacy and Tolerability of Levodropropizine and Clobutinol in Elderly Patients with Nonproductive Cough. Clin. Drug Invest. 14, 175–182 (1997). https://doi.org/10.2165/00044011-199714030-00003