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MedKoo Cat#: 124754 | Name: ML171

Description:

WARNING: This product is for research use only, not for human or veterinary use.

ML-171 is a NOX inhibitor.

Chemical Structure

ML171
ML171
CAS#6631-94-3

Theoretical Analysis

MedKoo Cat#: 124754

Name: ML171

CAS#: 6631-94-3

Chemical Formula: C14H11NOS

Exact Mass: 241.0600

Molecular Weight: 241.31

Elemental Analysis: C, 69.68; H, 4.59; N, 5.80; O, 6.63; S, 13.29

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
ML171; ML 171; ML-171; 2-Acetylphenothiazine; 6631-94-3; 1-(10H-Phenothiazin-2-yl)ethanone; ML171; Ethanone, 1-(10H-phenothiazin-2-yl)-
IUPAC/Chemical Name
1-(10H-phenothiazin-2-yl)ethanone
InChi Key
JWGBOHJGWOPYCL-UHFFFAOYSA-N
InChi Code
InChI=1S/C14H11NOS/c1-9(16)10-6-7-14-12(8-10)15-11-4-2-3-5-13(11)17-14/h2-8,15H,1H3
SMILES Code
CC(C(C=C1N2)=CC=C1SC3=C2C=CC=C3)=O
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 241.31 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Oh SH, Ahn JS, Oh EJ, Kim YJ, Yook JM, Lim JH, Jung HY, Choi JY, Kim CD, Park SH, Kim YL, Cho JH. Single-Dose Toxicity Study on ML171, a Selective NOX1 Inhibitor, in Mice. Biomed Res Int. 2021 May 30;2021:5515478. doi: 10.1155/2021/5515478. PMID: 34195263; PMCID: PMC8181097. 2: Kumar S, Singh AK, Vinayak M. ML171, a specific inhibitor of NOX1 attenuates formalin induced nociceptive sensitization by inhibition of ROS mediated ERK1/2 signaling. Neurochem Int. 2019 Oct;129:104466. doi: 10.1016/j.neuint.2019.104466. Epub 2019 May 23. PMID: 31129114. 3: da Silva BTA, Peloi KE, Ximenes VF, Nakamura CV, de Oliveira Silva Lautenschlager S. 2-acetylphenothiazine protects L929 fibroblasts against UVB- induced oxidative damage. J Photochem Photobiol B. 2021 Mar;216:112130. doi: 10.1016/j.jphotobiol.2021.112130. Epub 2021 Jan 23. PMID: 33561688.