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MedKoo Cat#: 558109 | Name: Sorbitol

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Sorbitol is a polyhydric alcohol. Sorbitol occurs naturally and is also produced synthetically from glucose.

Chemical Structure

Sorbitol
Sorbitol
CAS#50-70-4

Theoretical Analysis

MedKoo Cat#: 558109

Name: Sorbitol

CAS#: 50-70-4

Chemical Formula: C6H14O6

Exact Mass: 182.0800

Molecular Weight: 182.17

Elemental Analysis: C, 39.56; H, 7.75; O, 52.69

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Synonym
D-Sorbitol; Glucitol;
IUPAC/Chemical Name
D-Glucitol
InChi Key
FBPFZTCFMRRESA-JGWLITMVSA-N
InChi Code
InChI=1S/C6H14O6/c7-1-3(9)5(11)6(12)4(10)2-8/h3-12H,1-2H2/t3-,4+,5-,6-/m1/s1
SMILES Code
OC[C@@H]([C@H]([C@@H]([C@@H](CO)O)O)O)O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 182.17 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Ayoub I, Oh MS, Gupta R, McFarlane M, Babinska A, Salifu MO. Colon Necrosis Due to Sodium Polystyrene Sulfonate with and without Sorbitol: An Experimental Study in Rats. PLoS One. 2015 Sep 28;10(9):e0137636. doi: 10.1371/journal.pone.0137636. eCollection 2015. PubMed PMID: 26413782; PubMed Central PMCID: PMC4587365. 2: Piedmonte DM, Hair A, Baker P, Brych L, Nagapudi K, Lin H, Cao W, Hershenson S, Ratnaswamy G. Sorbitol crystallization-induced aggregation in frozen mAb formulations. J Pharm Sci. 2015 Feb;104(2):686-97. doi: 10.1002/jps.24141. Epub 2014 Sep 12. PubMed PMID: 25219372. 3: Pazhang M, Mehrnejad F, Pazhang Y, Falahati H, Chaparzadeh N. Effect of sorbitol and glycerol on the stability of trypsin and difference between their stabilization effects in the various solvents. Biotechnol Appl Biochem. 2016 Mar-Apr;63(2):206-13. doi: 10.1002/bab.1366. Epub 2015 Jun 4. PubMed PMID: 25757511. 4: Cardoso FS, Araujo-Lima CF, Aiub CA, Felzenszwalb I. Exposure to sorbitol during lactation causes metabolic alterations and genotoxic effects in rat offspring. Toxicol Lett. 2016 Oct 17;260:36-45. doi: 10.1016/j.toxlet.2016.08.018. Epub 2016 Aug 21. PubMed PMID: 27553672. 5: Kamimura A, Murata K, Tanaka Y, Okagawa T, Matsumoto H, Kaiso K, Yoshimoto M. Rapid conversion of sorbitol to isosorbide in hydrophobic ionic liquids under microwave irradiation. ChemSusChem. 2014 Dec;7(12):3257-9. doi: 10.1002/cssc.201402655. Epub 2014 Sep 15. PubMed PMID: 25223397. 6: Li J, Fan K, Guan X, Yu Y, Song J. Self-assembly mechanism of 1,3:2,4-di(3,4-dichlorobenzylidene)-D-sorbitol and control of the supramolecular chirality. Langmuir. 2014 Nov 11;30(44):13422-9. doi: 10.1021/la5034178. Epub 2014 Oct 29. PubMed PMID: 25318070. 7: Lai WC, Chen CC. Novel poly(ethylene glycol) gel electrolytes prepared using self-assembled 1,3:2,4-dibenzylidene-D-sorbitol. Soft Matter. 2014 Jan 14;10(2):312-9. doi: 10.1039/c3sm52430b. PubMed PMID: 24651903. 8: Gustini L, Lavilla C, de Ilarduya AM, Muñoz-Guerra S, Koning CE. Isohexide and Sorbitol-Derived, Enzymatically Synthesized Renewable Polyesters with Enhanced T(g). Biomacromolecules. 2016 Oct 10;17(10):3404-3416. Epub 2016 Sep 28. PubMed PMID: 27635782. 9: An K, Hu F, Bao J. Simultaneous saccharification of inulin and starch using commercial glucoamylase and the subsequent bioconversion to high titer sorbitol and gluconic acid. Appl Biochem Biotechnol. 2013 Dec;171(8):2093-104. doi: 10.1007/s12010-013-0278-z. Epub 2013 Sep 12. PubMed PMID: 24026410. 10: Pojprasath T, Lohachit C, Techakumphu M, Stout T, Tharasanit T. Improved cryopreservability of stallion sperm using a sorbitol-based freezing extender. Theriogenology. 2011 Jun;75(9):1742-9. doi: 10.1016/j.theriogenology.2011.01.014. Epub 2011 Mar 31. PubMed PMID: 21458054. 11: Bahrami H, Zahedi M, Moosavi-Movahedi AA, Azizian H, Amanlou M. Theoretical investigation of interaction of sorbitol molecules with alcohol dehydrogenase in aqueous solution using molecular dynamics simulation. Cell Biochem Biophys. 2011 Mar;59(2):79-88. doi: 10.1007/s12013-010-9116-x. PubMed PMID: 20844983. 12: Chong BF, Abeydeera WP, Glassop D, Bonnett GD, O'Shea MG, Brumbley SM. Co-ordinated synthesis of gentiobiitol and sorbitol, evidence of sorbitol glycosylation in transgenic sugarcane. Phytochemistry. 2010 May;71(7):736-41. doi: 10.1016/j.phytochem.2010.01.014. Epub 2010 Mar 1. PubMed PMID: 20193955. 13: Filip M, Vlassa M, Coman V, Halmagyi A. Simultaneous determination of glucose, fructose, sucrose and sorbitol in the leaf and fruit peel of different apple cultivars by the HPLC-RI optimized method. Food Chem. 2016 May 15;199:653-9. doi: 10.1016/j.foodchem.2015.12.060. Epub 2015 Dec 12. PubMed PMID: 26776021. 14: Sefcovicová J, Vikartovská A, Pätoprstý V, Magdolen P, Katrlík J, Tkac J, Gemeiner P. Off-line FIA monitoring of D-sorbitol consumption during L-sorbose production using a sorbitol biosensor. Anal Chim Acta. 2009 Jun 30;644(1-2):68-71. doi: 10.1016/j.aca.2009.04.012. Epub 2009 Apr 16. PubMed PMID: 19463564. 15: Assev S, Rölla G. Does the presence of xylitol in a sorbitol-containing chewing gum affect the adaptation to sorbitol by dental plaque? Scand J Dent Res. 1994 Oct;102(5):281-3. PubMed PMID: 7817153. 16: Rumessen JJ, Gudmand-Høyer E. Functional bowel disease: malabsorption and abdominal distress after ingestion of fructose, sorbitol, and fructose-sorbitol mixtures. Gastroenterology. 1988 Sep;95(3):694-700. PubMed PMID: 3396816. 17: Schüttert JB, Fiedler GM, Grupp C, Blaschke S, Grunewald RW. Sorbitol transport in rat renal inner medullary interstitial cells. Kidney Int. 2002 Apr;61(4):1407-15. PubMed PMID: 11918747. 18: Svensater G, Hamilton IR. Sorbitol transport by Streptococcus sanguis 160. Oral Microbiol Immunol. 1991 Jun;6(3):160-8. PubMed PMID: 1945499. 19: Assev S, Rølla G. Sorbitol increases the growth inhibition of xylitol on Strep. mutans OMZ 176. Acta Pathol Microbiol Immunol Scand B. 1986 Aug;94(4):231-7. PubMed PMID: 3751577. 20: Kracke GR, Preston GG, Stanley TH. Identification of a sorbitol permease in human erythrocytes. Am J Physiol. 1994 Feb;266(2 Pt 1):C343-50. PubMed PMID: 8141248.

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